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2zks

From Proteopedia

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{{Seed}}
 
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[[Image:2zks.png|left|200px]]
 
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==Structural insights into the proteolytic machinery of apoptosis-inducing Granzyme M==
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The line below this paragraph, containing "STRUCTURE_2zks", creates the "Structure Box" on the page.
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<StructureSection load='2zks' size='340' side='right'caption='[[2zks]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zks]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZKS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZKS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0QE:CHLOROMETHANE'>0QE</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2zks| PDB=2zks | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zks FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zks OCA], [https://pdbe.org/2zks PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zks RCSB], [https://www.ebi.ac.uk/pdbsum/2zks PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zks ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRAM_HUMAN GRAM_HUMAN] Cleaves peptide substrates after methionine, leucine, and norleucine. Physiological substrates include EZR, alpha-tubulins and the apoptosis inhibitor BIRC5/Survivin. Promotes caspase activation and subsequent apoptosis of target cells.<ref>PMID:18523284</ref> <ref>PMID:20406824</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zk/2zks_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zks ConSurf].
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<div style="clear:both"></div>
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===Structural insights into the proteolytic machinery of apoptosis-inducing Granzyme M===
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==See Also==
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*[[Granzyme|Granzyme]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19542453 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19542453}}
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==About this Structure==
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2ZKS is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZKS OCA].
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==Reference==
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<ref group="xtra">PMID:19542453</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fan, Z S.]]
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[[Category: Large Structures]]
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[[Category: Hua, G Q.]]
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[[Category: Fan ZS]]
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[[Category: Liu, K.]]
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[[Category: Hua GQ]]
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[[Category: Sun, F.]]
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[[Category: Liu K]]
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[[Category: Wang, L.]]
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[[Category: Sun F]]
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[[Category: Wu, L F.]]
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[[Category: Wang L]]
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[[Category: Yang, X.]]
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[[Category: Wu LF]]
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[[Category: Zhai, Y J.]]
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[[Category: Yang X]]
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[[Category: Cytolysis]]
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[[Category: Zhai YJ]]
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[[Category: Glycoprotein]]
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[[Category: Granzyme]]
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[[Category: Hydrolase]]
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[[Category: Secreted]]
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[[Category: Serine protease]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 8 09:32:07 2009''
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Current revision

Structural insights into the proteolytic machinery of apoptosis-inducing Granzyme M

PDB ID 2zks

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