3a1g

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{{Seed}}
 
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[[Image:3a1g.png|left|200px]]
 
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==High-Resolution Crystal Structure of RNA polymerase PB1-PB2 subunits from Influenza A Virus==
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The line below this paragraph, containing "STRUCTURE_3a1g", creates the "Structure Box" on the page.
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<StructureSection load='3a1g' size='340' side='right'caption='[[3a1g]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3a1g]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Puerto_Rico/8/1934(H1N1)) Influenza A virus (A/Puerto Rico/8/1934(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A1G FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3a1g| PDB=3a1g | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a1g OCA], [https://pdbe.org/3a1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a1g RCSB], [https://www.ebi.ac.uk/pdbsum/3a1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a1g ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RDRP_I34A1 RDRP_I34A1] RNA-dependent RNA polymerase which is responsible for replication and transcription of virus segments. Binds the promoter sequence of the encapsidated viral RNA. Displays an endonuclease activity involved in cap-stealing. Cleaves cellular pre-mRNA to generate primers for viral transcription.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Influenza virus RNA-dependent RNA polymerase is a multi-functional heterotrimer, which uses a 'cap-snatching' mechanism to produce viral mRNA. Host cell mRNA is cleaved to yield a cap-bearing oligonucleotide, which can be extended using viral genomic RNA as a template. The cap-binding and endonuclease activities are only activated once viral genomic RNA is bound. This requires signalling from the RNA-binding PB1 subunit to the cap-binding PB2 subunit, and the interface between these two subunits is essential for the polymerase activity. We have defined this interaction surface by protein crystallography and tested the effects of mutating contact residues on the function of the holo-enzyme. This novel interface is surprisingly small, yet, it has a crucial function in regulating the 250 kDa polymerase complex and is completely conserved among avian and human influenza viruses.
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===High-Resolution Crystal Structure of RNA polymerase PB1-PB2 subunits from Influenza A Virus===
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Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase.,Sugiyama K, Obayashi E, Kawaguchi A, Suzuki Y, Tame JR, Nagata K, Park SY EMBO J. 2009 Jun 17;28(12):1803-11. Epub 2009 May 21. PMID:19461581<ref>PMID:19461581</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3a1g" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19461581 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19461581}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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3A1G is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Influenza_a_virus_(a/puerto_rico/8/34(h1n1)) Influenza a virus (a/puerto rico/8/34(h1n1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A1G OCA].
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[[Category: Obayashi E]]
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[[Category: Park S-Y]]
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==Reference==
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[[Category: Sugiyama K]]
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<ref group="xtra">PMID:19461581</ref><references group="xtra"/>
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Obayashi, E.]]
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[[Category: Park, S Y.]]
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[[Category: Sugiyama, K.]]
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[[Category: Crystal structure]]
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[[Category: Influenza virus]]
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[[Category: Mitochondrion]]
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[[Category: Mrna capping]]
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[[Category: Mrna processing]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Nucleus]]
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[[Category: Rna polymerase]]
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[[Category: Rna replication]]
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[[Category: Rna-directed rna polymerase]]
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[[Category: Transferase]]
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[[Category: Virion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 8 12:52:48 2009''
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Current revision

High-Resolution Crystal Structure of RNA polymerase PB1-PB2 subunits from Influenza A Virus

PDB ID 3a1g

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