1b4y

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1b4y" size="450" color="white" frame="true" align="right" spinBox="true" caption="1b4y" /> '''STRUCTURE AND MECHANISM OF FORMATION OF THE ...)
Current revision (23:19, 27 December 2023) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1b4y.gif|left|200px]]<br /><applet load="1b4y" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1b4y" />
 
-
'''STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.'''<br />
 
-
==Overview==
+
==STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.==
-
H-DNA, thought to play a regulatory role in transcription, exists in two, isomeric forms, H-y3 and H-y5. We present the first solution structure of, a DNA fragment representing the H-y5 fold. The structure shows the H-y5, triple helix, and for the first time how in an H-DNA isomer the purine, strand extension interacts with the triplex loop. It gives direct insight, into the mechanism of H-DNA formation, and explains a host of biochemical, and biophysical data on the relative stability of the H-DNA isomers. In, addition, the observed interaction of the purine strand extension and the, triplex loop provides new clues to the design of clamp-type triple, helix-forming oligonucleotides.
+
<StructureSection load='1b4y' size='340' side='right'caption='[[1b4y]]' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[1b4y]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1B4Y FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1b4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b4y OCA], [https://pdbe.org/1b4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1b4y RCSB], [https://www.ebi.ac.uk/pdbsum/1b4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1b4y ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
H-DNA, thought to play a regulatory role in transcription, exists in two isomeric forms, H-y3 and H-y5. We present the first solution structure of a DNA fragment representing the H-y5 fold. The structure shows the H-y5 triple helix, and for the first time how in an H-DNA isomer the purine strand extension interacts with the triplex loop. It gives direct insight into the mechanism of H-DNA formation, and explains a host of biochemical and biophysical data on the relative stability of the H-DNA isomers. In addition, the observed interaction of the purine strand extension and the triplex loop provides new clues to the design of clamp-type triple helix-forming oligonucleotides.
-
==About this Structure==
+
Structure and mechanism of formation of the H-y5 isomer of an intramolecular DNA triple helix.,van Dongen MJ, Doreleijers JF, van der Marel GA, van Boom JH, Hilbers CW, Wijmenga SS Nat Struct Biol. 1999 Sep;6(9):854-9. PMID:10467098<ref>PMID:10467098</ref>
-
1B4Y is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1B4Y OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Structure and mechanism of formation of the H-y5 isomer of an intramolecular DNA triple helix., van Dongen MJ, Doreleijers JF, van der Marel GA, van Boom JH, Hilbers CW, Wijmenga SS, Nat Struct Biol. 1999 Sep;6(9):854-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10467098 10467098]
+
</div>
-
[[Category: Protein complex]]
+
<div class="pdbe-citations 1b4y" style="background-color:#fffaf0;"></div>
-
[[Category: Boom, J.H.Van.]]
+
== References ==
-
[[Category: Dongen, M.J.P.Van.]]
+
<references/>
-
[[Category: Doreleijers, J.F.]]
+
__TOC__
-
[[Category: Hilbers, C.W.]]
+
</StructureSection>
-
[[Category: Marel, G.A.Van.Der.]]
+
[[Category: Large Structures]]
-
[[Category: Wijmenga, S.S.]]
+
[[Category: Doreleijers JF]]
-
[[Category: dna]]
+
[[Category: Hilbers CW]]
-
[[Category: h-dna]]
+
[[Category: Van Boom JH]]
-
[[Category: triple helix]]
+
[[Category: Van Der Marel GA]]
-
 
+
[[Category: Van Dongen MJP]]
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:43:45 2007''
+
[[Category: Wijmenga SS]]

Current revision

STRUCTURE AND MECHANISM OF FORMATION OF THE H-Y5 ISOMER OF AN INTRAMOLECULAR DNA TRIPLE HELIX.

PDB ID 1b4y

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1b4y"
Personal tools