1s2x

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(New page: 200px<br /><applet load="1s2x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1s2x, resolution 1.90&Aring;" /> '''Crystal structure of...)
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[[Image:1s2x.jpg|left|200px]]<br /><applet load="1s2x" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1s2x, resolution 1.90&Aring;" />
 
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'''Crystal structure of Cag-Z from Helicobacter pylori'''<br />
 
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==Overview==
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==Crystal structure of Cag-Z from Helicobacter pylori==
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CagZ, a 23 kDa protein encoded by the cagZ gene (HP0526) of the cag, pathogenicity island of Helicobacter pylori, has been cloned, over-expressed, purified and its three-dimensional structure determined., The protein consists of a single compact L-shaped domain, composed of, seven alpha-helices including about 70% of the total residues., Three-dimensional homology searches did not reveal structural homologues, and CagZ can be considered representative of a new protein fold. The, presence of a disordered C-terminal tail and the nature of the molecular, surface suggest that CagZ may participate in the interaction of effector, proteins with one or more components of the H.pylori type IV secretion, system on the cytoplasmic side of the inner membrane.
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<StructureSection load='1s2x' size='340' side='right'caption='[[1s2x]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1s2x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S2X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s2x OCA], [https://pdbe.org/1s2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s2x RCSB], [https://www.ebi.ac.uk/pdbsum/1s2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s2x ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9JMX9_HELPX Q9JMX9_HELPX]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CagZ, a 23 kDa protein encoded by the cagZ gene (HP0526) of the cag pathogenicity island of Helicobacter pylori, has been cloned, over-expressed, purified and its three-dimensional structure determined. The protein consists of a single compact L-shaped domain, composed of seven alpha-helices including about 70% of the total residues. Three-dimensional homology searches did not reveal structural homologues, and CagZ can be considered representative of a new protein fold. The presence of a disordered C-terminal tail and the nature of the molecular surface suggest that CagZ may participate in the interaction of effector proteins with one or more components of the H.pylori type IV secretion system on the cytoplasmic side of the inner membrane.
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==About this Structure==
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Crystal structure of CagZ, a protein from the Helicobacter pylori pathogenicity island that encodes for a type IV secretion system.,Cendron L, Seydel A, Angelini A, Battistutta R, Zanotti G J Mol Biol. 2004 Jul 16;340(4):881-9. PMID:15223328<ref>PMID:15223328</ref>
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1S2X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori] with IPA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1S2X OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Crystal structure of CagZ, a protein from the Helicobacter pylori pathogenicity island that encodes for a type IV secretion system., Cendron L, Seydel A, Angelini A, Battistutta R, Zanotti G, J Mol Biol. 2004 Jul 16;340(4):881-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15223328 15223328]
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</div>
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<div class="pdbe-citations 1s2x" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Angelini, A.]]
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[[Category: Angelini A]]
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[[Category: Battistutta, R.]]
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[[Category: Battistutta R]]
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[[Category: Cendron, L.]]
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[[Category: Cendron L]]
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[[Category: Seydel, A.]]
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[[Category: Seydel A]]
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[[Category: Zanotti, G.]]
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[[Category: Zanotti G]]
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[[Category: IPA]]
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[[Category: cag pathogenicity island]]
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[[Category: cag-z]]
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[[Category: helicobacter pylori]]
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[[Category: type iv secretion system]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:48:02 2007''
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Current revision

Crystal structure of Cag-Z from Helicobacter pylori

PDB ID 1s2x

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