1jnu

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(New page: 200px<br /><applet load="1jnu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jnu, resolution 2.60&Aring;" /> '''Photoexcited structu...)
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[[Image:1jnu.gif|left|200px]]<br /><applet load="1jnu" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jnu, resolution 2.60&Aring;" />
 
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'''Photoexcited structure of the plant photoreceptor domain, phy3 LOV2'''<br />
 
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==Overview==
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==Photoexcited structure of the plant photoreceptor domain, phy3 LOV2==
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The phototropins are flavoprotein kinases that control phototropic, bending, light-induced chloroplast movement, and stomatal opening in, plants. Two flavin mononucleotide binding light, oxygen, or voltage (LOV), domains are the sites for initial photochemistry in these blue light, photoreceptors. We have determined the steady state, photoexcited crystal, structure of a flavin-bound LOV domain. The structure reveals a unique, photochemical switch in the flavin binding pocket in which the absorption, of light drives the formation of a reversible covalent bond between a, highly conserved Cys residue and the flavin cofactor. This provides a, molecular picture of a cysteinyl-flavin covalent adduct, the presumed, signaling species that leads to phototropin kinase activation and, subsequent signal transduction. We identify closely related LOV domains in, two eubacterial proteins that suggests the light-induced conformational, change evident in this structure is an ancient biomolecular response to, light, arising before the appearance of plants.
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<StructureSection load='1jnu' size='340' side='right'caption='[[1jnu]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jnu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Adiantum_capillus-veneris Adiantum capillus-veneris]. The March 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Phototropin'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_3 10.2210/rcsb_pdb/mom_2015_3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JNU FirstGlance]. <br>
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1JNU is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Eukaryota Eukaryota] with FMN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JNU OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jnu OCA], [https://pdbe.org/1jnu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jnu RCSB], [https://www.ebi.ac.uk/pdbsum/1jnu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jnu ProSAT]</span></td></tr>
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Photoexcited structure of a plant photoreceptor domain reveals a light-driven molecular switch., Crosson S, Moffat K, Plant Cell. 2002 May;14(5):1067-75. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12034897 12034897]
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</table>
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[[Category: Eukaryota]]
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== Function ==
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[[Category: Single protein]]
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[https://www.uniprot.org/uniprot/Q9ZWQ6_ADICA Q9ZWQ6_ADICA]
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[[Category: Crosson, S.]]
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== Evolutionary Conservation ==
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[[Category: Moffat, K.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: FMN]]
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Check<jmol>
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[[Category: cysteinyl-flavin adduct]]
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<jmolCheckbox>
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[[Category: light-driven bond]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/1jnu_consurf.spt"</scriptWhenChecked>
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[[Category: lov]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: pas]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: photochemistry]]
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</jmolCheckbox>
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[[Category: photoexcited]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jnu ConSurf].
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[[Category: phototropin]]
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<div style="clear:both"></div>
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[[Category: phy3]]
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__TOC__
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[[Category: plant photoreceptor]]
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</StructureSection>
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[[Category: Adiantum capillus-veneris]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:55:40 2007''
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[[Category: Large Structures]]
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[[Category: Phototropin]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Crosson S]]
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[[Category: Moffat K]]

Current revision

Photoexcited structure of the plant photoreceptor domain, phy3 LOV2

PDB ID 1jnu

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