1nxi
From Proteopedia
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(New page: 200px<br /><applet load="1nxi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nxi" /> '''Solution structure of Vibrio cholerae protei...) |
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| - | [[Image:1nxi.gif|left|200px]]<br /><applet load="1nxi" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1nxi" /> | ||
| - | '''Solution structure of Vibrio cholerae protein VC0424'''<br /> | ||
| - | == | + | ==Solution structure of Vibrio cholerae protein VC0424== |
| - | The structure of Vibrio cholerae protein VC0424 was determined by NMR | + | <StructureSection load='1nxi' size='340' side='right'caption='[[1nxi]]' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1nxi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae Vibrio cholerae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NXI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NXI FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nxi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nxi OCA], [https://pdbe.org/1nxi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nxi RCSB], [https://www.ebi.ac.uk/pdbsum/1nxi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nxi ProSAT], [https://www.topsan.org/Proteins/NESGC/1nxi TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9KUU1_VIBCH Q9KUU1_VIBCH] Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity).[HAMAP-Rule:MF_01888] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nx/1nxi_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nxi ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The structure of Vibrio cholerae protein VC0424 was determined by NMR spectroscopy. VC0424 belongs to a conserved family of bacterial proteins of unknown function (COG 3076). The structure has an alpha-beta sandwich architecture consisting of two layers: a four-stranded antiparallel beta-sheet and three side-by-side alpha-helices. The secondary structure elements have the order alphabetaalphabetabetaalphabeta along the sequence. This fold is the same as the ferredoxin-like fold, except with an additional long N-terminal helix, making it a variation on this common motif. A cluster of conserved surface residues on the beta-sheet side of the protein forms a pocket that may be important for the biological function of this conserved family of proteins. | ||
| - | + | Solution structure of Vibrio cholerae protein VC0424: a variation of the ferredoxin-like fold.,Ramelot TA, Ni S, Goldsmith-Fischman S, Cort JR, Honig B, Kennedy MA Protein Sci. 2003 Jul;12(7):1556-61. PMID:12824501<ref>PMID:12824501</ref> | |
| - | + | ||
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | [[Category: | + | <div class="pdbe-citations 1nxi" style="background-color:#fffaf0;"></div> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Vibrio cholerae]] | [[Category: Vibrio cholerae]] | ||
| - | [[Category: Cort | + | [[Category: Cort JR]] |
| - | [[Category: Goldsmith-Fischman | + | [[Category: Goldsmith-Fischman S]] |
| - | [[Category: Honig | + | [[Category: Honig B]] |
| - | [[Category: Kennedy | + | [[Category: Kennedy MA]] |
| - | + | [[Category: Ni S]] | |
| - | [[Category: Ni | + | [[Category: Ramelot TA]] |
| - | [[Category: Ramelot | + | |
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Current revision
Solution structure of Vibrio cholerae protein VC0424
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