1nxm

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(New page: 200px<br /><applet load="1nxm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nxm, resolution 1.30&Aring;" /> '''The high resolution ...)
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[[Image:1nxm.gif|left|200px]]<br /><applet load="1nxm" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1nxm, resolution 1.30&Aring;" />
 
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'''The high resolution structures of RmlC from Streptococcus suis'''<br />
 
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==Overview==
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==The high resolution structures of RmlC from Streptococcus suis==
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Nature achieves the epimerization of carbohydrates by a variety of, chemical routes. One common route is that performed by the class of enzyme, defined by dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase (RmlC) from the, rhamnose pathway. Earlier studies failed to identify the key residues in, catalysis. We report the 1.3 A structure of RmlC from Streptococcus suis, type 2 and its complexes with dTDP-D-glucose and dTDP-D-xylose. The, streptococcal RmlC enzymes belong to a separate subgroup, sharing only 25%, identity with RmlC from other bacteria, yet the S. suis enzyme has similar, kinetic properties and structure to other RmlC enzymes. Structure, sequence alignment, and mutational analysis have now allowed reliable, identification of the catalytic residues and their roles.
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<StructureSection load='1nxm' size='340' side='right'caption='[[1nxm]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1nxm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_suis Streptococcus suis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NXM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nxm OCA], [https://pdbe.org/1nxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nxm RCSB], [https://www.ebi.ac.uk/pdbsum/1nxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nxm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8GIQ0_STRSU Q8GIQ0_STRSU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nx/1nxm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nxm ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1NXM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_suis Streptococcus suis]. Active as [http://en.wikipedia.org/wiki/dTDP-4-dehydrorhamnose_3,5-epimerase dTDP-4-dehydrorhamnose 3,5-epimerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.1.3.13 5.1.3.13] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NXM OCA].
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*[[RmlC|RmlC]]
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__TOC__
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==Reference==
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</StructureSection>
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High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme., Dong C, Major LL, Allen A, Blankenfeldt W, Maskell D, Naismith JH, Structure. 2003 Jun;11(6):715-23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12791259 12791259]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Streptococcus suis]]
[[Category: Streptococcus suis]]
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[[Category: dTDP-4-dehydrorhamnose 3,5-epimerase]]
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[[Category: Allen A]]
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[[Category: Allen, A.]]
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[[Category: Blankenfeldt W]]
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[[Category: Blankenfeldt, W.]]
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[[Category: Dong C]]
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[[Category: Dong, C.]]
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[[Category: Major LL]]
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[[Category: Major, L.L.]]
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[[Category: Maskell D]]
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[[Category: Maskell, D.]]
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[[Category: Naismith JH]]
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[[Category: Naismith, J.H.]]
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[[Category: jelly roll-like structure; beta sheet]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:58:48 2007''
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Current revision

The high resolution structures of RmlC from Streptococcus suis

PDB ID 1nxm

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