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1joh

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(New page: 200px<br /><applet load="1joh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1joh, resolution 1.4&Aring;" /> '''THE STRUCTURE OF ANTI...)
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[[Image:1joh.jpg|left|200px]]<br /><applet load="1joh" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1joh, resolution 1.4&Aring;" />
 
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'''THE STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE-ACTIVE PEPTIDE'''<br />
 
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==Overview==
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==THE STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE-ACTIVE PEPTIDE==
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BACKGROUND: Antiamoebin is a member of the peptaibol family of, polypeptides and has a unique antibiotic activity: it acts as an, antiamoebic agent, but does not effectively haemolyze erythrocytes even, though it does exhibit membrane-modifying activity. RESULTS: The structure, of antiamoebin I has been determined by X-ray crystallography at 1.4 A, resolution. The molecule forms a helical structure, which, as a result of, the presence of a number of proline and hydroxyproline residues, has a, deep bend in the middle. Circular dichroism spectroscopy, single-channel, conductance studies and fluorescence diffusion studies suggest a mode of, ion transport that is entirely different from that of the other two, members of the peptaibol family (alamethicin and zervamicin) whose, structures and functions have been examined in detail. CONCLUSIONS: The, structure of the polypeptide has been determined and a functional model, for its mode of action in membranes is presented. Although under some, conditions antiamoebin may form ion channels, unlike the closely related, alamethicin and zervamicin polypeptides, its major membrane-modifying, activity appears to be as an ion carrier.
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<StructureSection load='1joh' size='340' side='right'caption='[[1joh]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1joh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Emericellopsis Emericellopsis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JOH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JOH FirstGlance]. <br>
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1JOH is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Emercelliopsis_sp. Emercelliopsis sp.] with ACE and MOH as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JOH OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=DIV:D-ISOVALINE'>DIV</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=PHL:L-PHENYLALANINOL'>PHL</scene>, <scene name='pdbligand=PRD_000161:Antiamoebin+1'>PRD_000161</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1joh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1joh OCA], [https://pdbe.org/1joh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1joh RCSB], [https://www.ebi.ac.uk/pdbsum/1joh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1joh ProSAT]</span></td></tr>
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The structure and function of antiamoebin I, a proline-rich membrane-active polypeptide., Snook CF, Woolley GA, Oliva G, Pattabhi V, Wood SF, Blundell TL, Wallace BA, Structure. 1998 Jun 15;6(6):783-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9655831 9655831]
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</table>
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[[Category: Emercelliopsis sp.]]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Snook, C.F.]]
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[[Category: Emericellopsis]]
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[[Category: Wallace, B.A.]]
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[[Category: Large Structures]]
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[[Category: ACE]]
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[[Category: Snook CF]]
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[[Category: MOH]]
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[[Category: Wallace BA]]
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[[Category: antiamoebin]]
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[[Category: peptaibol]]
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[[Category: peptide antibiotic]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 23:58:57 2007''
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Current revision

THE STRUCTURE OF ANTIAMOEBIN I, A MEMBRANE-ACTIVE PEPTIDE

PDB ID 1joh

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