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3a4r
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3a4r is ON HOLD until Paper Publication Authors: Arita, K., Ikeda, Y., Ariyoshi, M., Tochio, H., Saitoh, H. Description: The crystal structure of S...) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of SUMO-like domain 2 in Nip45== |
| - | + | <StructureSection load='3a4r' size='340' side='right'caption='[[3a4r]], [[Resolution|resolution]] 1.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3a4r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A4R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a4r OCA], [https://pdbe.org/3a4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a4r RCSB], [https://www.ebi.ac.uk/pdbsum/3a4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a4r ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NF2IP_MOUSE NF2IP_MOUSE] In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.<ref>PMID:20133688</ref> <ref>PMID:20077568</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a4/3a4r_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3a4r ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Arita K]] | ||
| + | [[Category: Ariyoshi M]] | ||
| + | [[Category: Ikeda Y]] | ||
| + | [[Category: Saitoh H]] | ||
| + | [[Category: Sekiyama N]] | ||
| + | [[Category: Shirakawa M]] | ||
| + | [[Category: Tochio H]] | ||
Current revision
The crystal structure of SUMO-like domain 2 in Nip45
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Categories: Large Structures | Mus musculus | Arita K | Ariyoshi M | Ikeda Y | Saitoh H | Sekiyama N | Shirakawa M | Tochio H
