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1bd1

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(New page: 200px<br /><applet load="1bd1" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bd1, resolution 1.600&Aring;" /> '''CRYSTALLOGRAPHIC ST...)
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[[Image:1bd1.gif|left|200px]]<br /><applet load="1bd1" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1bd1, resolution 1.600&Aring;" />
 
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'''CRYSTALLOGRAPHIC STUDY OF ONE TURN OF G/C-RICH B-DNA'''<br />
 
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==Overview==
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==CRYSTALLOGRAPHIC STUDY OF ONE TURN OF G/C-RICH B-DNA==
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The DNA decamer d(CCAGGCCTGG) has been studied by X-ray crystallography., At a nominal resolution of 1.6 A, the structure was refined to R = 16.9%, using stereochemical restraints. The oligodeoxyribonucleotide forms a, straight B-DNA double helix with crystallographic dyad symmetry and ten, base-pairs per turn. In the crystal lattice, DNA fragments stack, end-to-end along the c-axis to form continuous double helices. The overall, helical structure and, notably, the groove dimensions of the decamer are, more similar to standard, fiber diffraction-determined B-DNA than A-tract, DNA. A unique stacking geometry is observed at the CA/TG base-pair step, where an increased rotation about the helix axis and a sliding motion of, the base-pairs along their long axes leads to a superposition of the base, rings with neighboring carbonyl and amino functions. Three-center, (bifurcated) hydrogen bonds are possible at the CC/GG base-pair steps of, the decamer. In their common sequence elements, d(CCAGGCCTGG) and the, related G.A mismatch decamer d(CCAAGATTGG) show very similar, three-dimensional structures, except that d(CCAGGCCTGG) appears to have a, less regularly hydrated minor groove. The paucity of minor groove, hydration in the center of the decamer may be a general feature of, G/C-rich DNA and explain its relative instability in the B-form of DNA.
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<StructureSection load='1bd1' size='340' side='right'caption='[[1bd1]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1bd1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BD1 FirstGlance]. <br>
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1BD1 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with TEA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BD1 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TEA:TRIETHYLAMMONIUM+ION'>TEA</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bd1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bd1 OCA], [https://pdbe.org/1bd1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bd1 RCSB], [https://www.ebi.ac.uk/pdbsum/1bd1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bd1 ProSAT]</span></td></tr>
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Crystallographic study of one turn of G/C-rich B-DNA., Heinemann U, Alings C, J Mol Biol. 1989 Nov 20;210(2):369-81. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=2600970 2600970]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Heinemann, U.]]
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</StructureSection>
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[[Category: TEA]]
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[[Category: Large Structures]]
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[[Category: b-dna]]
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[[Category: Heinemann U]]
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[[Category: double helix]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:01:58 2007''
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CRYSTALLOGRAPHIC STUDY OF ONE TURN OF G/C-RICH B-DNA

PDB ID 1bd1

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