3hr0

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{{Seed}}
 
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[[Image:3hr0.jpg|left|200px]]
 
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==Crystal structure of Homo sapiens Conserved Oligomeric Golgi subunit 4==
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The line below this paragraph, containing "STRUCTURE_3hr0", creates the "Structure Box" on the page.
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<StructureSection load='3hr0' size='340' side='right'caption='[[3hr0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3hr0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HR0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hr0 OCA], [https://pdbe.org/3hr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hr0 RCSB], [https://www.ebi.ac.uk/pdbsum/3hr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hr0 ProSAT]</span></td></tr>
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{{STRUCTURE_3hr0| PDB=3hr0 | SCENE= }}
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</table>
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== Disease ==
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===Crystal structure of Homo sapiens Conserved Oligomeric Golgi subunit 4===
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[https://www.uniprot.org/uniprot/COG4_HUMAN COG4_HUMAN] Defects in COG4 are the cause of congenital disorder of glycosylation type 2J (CDG2J) [MIM:[https://omim.org/entry/613489 613489]. It is a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.<ref>PMID:19651599</ref> <ref>PMID:19494034</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/COG4_HUMAN COG4_HUMAN] Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.<ref>PMID:19536132</ref>
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==About this Structure==
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== Evolutionary Conservation ==
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3HR0 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HR0 OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/3hr0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hr0 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Hughson, F M.]]
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[[Category: Large Structures]]
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[[Category: Jeffrey, P D.]]
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[[Category: Hughson FM]]
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[[Category: Nakamura, A.]]
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[[Category: Jeffrey PD]]
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[[Category: Richardson, B C.]]
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[[Category: Nakamura A]]
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[[Category: Ungar, D.]]
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[[Category: Richardson BC]]
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[[Category: Alternative splicing]]
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[[Category: Ungar D]]
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[[Category: Conserved oligomeric golgi complex]]
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[[Category: Exocyst]]
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[[Category: Golgi apparatus]]
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[[Category: Intracellular trafficking]]
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[[Category: Membrane]]
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[[Category: Multisubunit tethering complex]]
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[[Category: Phosphoprotein]]
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[[Category: Protein transport]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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[[Category: Vesicle tethering]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 22 20:44:51 2009''
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Current revision

Crystal structure of Homo sapiens Conserved Oligomeric Golgi subunit 4

PDB ID 3hr0

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