1fms

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1fms" size="450" color="white" frame="true" align="right" spinBox="true" caption="1fms, resolution 1.9&Aring;" /> '''Structure of complex ...)
Current revision (07:16, 7 February 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1fms.gif|left|200px]]<br /><applet load="1fms" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1fms, resolution 1.9&Aring;" />
 
-
'''Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)'''<br />
 
-
==Overview==
+
==Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)==
-
2,5-Bis-[4-(N-cyclobutyl-amidino)phenyl] furan and, 2,5-bis-[4-(N-cyclohexyl-amidino)phenyl] furan have activity against, Pneumocystis carinii and also show cytotoxicity against several tumour, cell lines. These activities are correlated with DNA-binding abilities;, the crystal structures of complexes with the DNA sequence d(CGCGAATTCGCG), is reported here. Interactions with, and effects on, the DNA minor groove, are found to be factors in the biological properties of these compounds.
+
<StructureSection load='1fms' size='340' side='right'caption='[[1fms]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1fms]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FMS FirstGlance]. <br>
-
1FMS is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with MG and D35 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1FMS OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D35:2,5-BIS{[4-(N-CYCLOHEXYLDIAMINOMETHYL)PHENYL]}FURAN'>D35</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fms OCA], [https://pdbe.org/1fms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fms RCSB], [https://www.ebi.ac.uk/pdbsum/1fms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fms ProSAT]</span></td></tr>
-
DNA minor groove interactions and the biological activity of 2,5-bis., Simpson IJ, Lee M, Kumar A, Boykin DW, Neidle S, Bioorg Med Chem Lett. 2000 Dec 4;10(23):2593-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11128631 11128631]
+
</table>
-
[[Category: Protein complex]]
+
__TOC__
-
[[Category: Boykin, D.W.]]
+
</StructureSection>
-
[[Category: Kumar, A.]]
+
[[Category: Large Structures]]
-
[[Category: Lee, M.]]
+
[[Category: Boykin DW]]
-
[[Category: Neidle, S.]]
+
[[Category: Kumar A]]
-
[[Category: Simpson, I.J.]]
+
[[Category: Lee M]]
-
[[Category: D35]]
+
[[Category: Neidle S]]
-
[[Category: MG]]
+
[[Category: Simpson IJ]]
-
[[Category: dna-drug minor groove complex]]
+
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:04:34 2007''
+

Current revision

Structure of complex between cyclohexyl-bis-furamidine and d(CGCGAATTCGCG)

PDB ID 1fms

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1fms"
Personal tools