1nzg

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(New page: 200px<br /><applet load="1nzg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1nzg, resolution 1.60&Aring;" /> '''Crystal structure of...)
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[[Image:1nzg.gif|left|200px]]<br /><applet load="1nzg" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1nzg, resolution 1.60&Aring;" />
 
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'''Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine'''<br />
 
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==Overview==
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==Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine==
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[structure: see text] Oligonucleotides with a novel, 2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] (2'-O-DMAEOE) modification, have been synthesized. This modification, a cationic analogue of the, 2'-O-(2-methoxyethyl) (2'-O-MOE) modification, exhibits high binding, affinity to target RNA (but not to DNA) and exceptional resistance to, nuclease degradation. Analysis of the crystal structure of a, self-complementary oligonucleotide containing a single 2'-O-DMAEOE, modification explains the importance of charge factors and gauche effects, on the observed antisense properties. 2'-O-DMAEOE modified, oligonucleotides are ideal candidates for antisense drugs.
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<StructureSection load='1nzg' size='340' side='right'caption='[[1nzg]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1nzg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NZG FirstGlance]. <br>
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1NZG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NZG OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3ME:2-O-{2-[2-(DIMETHYLAMINO)ETHOXY]ETHYL}-5-METHYLURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>3ME</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nzg OCA], [https://pdbe.org/1nzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nzg RCSB], [https://www.ebi.ac.uk/pdbsum/1nzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nzg ProSAT]</span></td></tr>
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2'-O-[2-[2-(N,N-dimethylamino)ethoxy]ethyl] modified oligonucleotides: symbiosis of charge interaction factors and stereoelectronic effects., Prhavc M, Prakash TP, Minasov G, Cook PD, Egli M, Manoharan M, Org Lett. 2003 Jun 12;5(12):2017-20. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12790517 12790517]
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</table>
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[[Category: Protein complex]]
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__TOC__
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[[Category: Egli, M.]]
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</StructureSection>
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[[Category: Manoharan, M.]]
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[[Category: Large Structures]]
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[[Category: Minasov, G.]]
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[[Category: Egli M]]
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[[Category: Prakash, T.P.]]
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[[Category: Manoharan M]]
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[[Category: Prhavc, M.]]
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[[Category: Minasov G]]
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[[Category: 2'-modified oligonucleotides]]
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[[Category: Prakash TP]]
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[[Category: a-dna]]
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[[Category: Prhavc M]]
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[[Category: crystal structure]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:06:30 2007''
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Current revision

Crystal structure of A-DNA decamer GCGTA(3ME)ACGC, with a modified 5-methyluridine

PDB ID 1nzg

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