2jxw

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{{Seed}}
 
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[[Image:2jxw.png|left|200px]]
 
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==Solution Structure of the Tandem WW Domains of FBP21==
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The line below this paragraph, containing "STRUCTURE_2jxw", creates the "Structure Box" on the page.
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<StructureSection load='2jxw' size='340' side='right'caption='[[2jxw]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JXW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jxw OCA], [https://pdbe.org/2jxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jxw RCSB], [https://www.ebi.ac.uk/pdbsum/2jxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jxw ProSAT]</span></td></tr>
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{{STRUCTURE_2jxw| PDB=2jxw | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/WBP4_HUMAN WBP4_HUMAN] Promotes pre-mRNA splicing. A spliceosome-associated protein; may play a role in cross-intron bridging of U1 and U2 snRNPs in the mammalian A complex.<ref>PMID:9724750</ref> <ref>PMID:19592703</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/2jxw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jxw ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human FBP21 (formin-binding protein 21) contains a matrin-type zinc finger and two tandem WW domains. It is a component of the spliceosomes and interacts with several established splicing factors. Here we demonstrate for the first time that FBP21 is an activator of pre-mRNA splicing in vivo and that its splicing activation function and interaction with the splicing factor SIPP1 (splicing factor that interacts with PQBP1 and PP1) are both mediated by the two tandem WW domains of group III. We determined the solution structure of the tandem WW domains of FBP21 and found that the WW domains recognize peptide ligands containing either group II (PPLP) or group III (PPR) motifs. The binding interfaces involve both the XP and XP2 grooves of the two WW domains. Significantly, the tandem WW domains of FBP21 are connected by a highly flexible region, enabling their simultaneous interaction with two proline-rich motifs of SIPP1. The strong interaction between SIPP1 and FBP21 can be explained by the conjugation of two low affinity interactions with the tandem WW domains. Our study provides a structural basis for understanding the molecular mechanism underlying the functional implication of FBP21 and the biological specificity of tandem WW domains.
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===Solution Structure of the Tandem WW Domains of FBP21===
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Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21).,Huang X, Beullens M, Zhang J, Zhou Y, Nicolaescu E, Lesage B, Hu Q, Wu J, Bollen M, Shi Y J Biol Chem. 2009 Sep 11;284(37):25375-87. Epub 2009 Jul 10. PMID:19592703<ref>PMID:19592703</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19592703}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2jxw" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19592703 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19592703}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2JXW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JXW OCA].
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==Reference==
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<ref group="xtra">PMID:19592703</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Huang, X.]]
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[[Category: Large Structures]]
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[[Category: Shi, Y.]]
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[[Category: Huang X]]
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[[Category: Wu, J.]]
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[[Category: Shi Y]]
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[[Category: Zhang, J.]]
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[[Category: Wu J]]
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[[Category: Fbp21]]
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[[Category: Zhang J]]
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[[Category: Formin binding protein]]
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[[Category: Metal-binding]]
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[[Category: Mrna processing]]
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[[Category: Mrna splicing]]
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[[Category: Nucleus]]
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[[Category: Polymorphism]]
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[[Category: Spliceosome]]
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[[Category: Wbp4]]
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[[Category: Ww domain]]
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[[Category: Ww domain containing protein]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 09:15:31 2009''
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Current revision

Solution Structure of the Tandem WW Domains of FBP21

PDB ID 2jxw

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