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1sd5

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(New page: 200px<br /><applet load="1sd5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sd5, resolution 1.68&Aring;" /> '''Crystal structure of...)
Current revision (08:29, 14 February 2024) (edit) (undo)
 
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[[Image:1sd5.gif|left|200px]]<br /><applet load="1sd5" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1sd5, resolution 1.68&Aring;" />
 
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'''Crystal structure of Rv1626'''<br />
 
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==Overview==
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==Crystal structure of Rv1626==
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We describe the crystal structure of Rv1626 from Mycobacterium, tuberculosis at 1.48 A resolution and the corresponding solution structure, determined from small angle X-ray scattering. The N-terminal domain shows, structural homology to the receiver domains found in bacterial, two-component systems. The C-terminal domain has high structural homology, to a recently discovered RNA binding domain involved in transcriptional, antitermination. The molecule in solution was found to be monomeric as it, is in the crystal, but in solution it undergoes a conformational change, that is triggered by changes in ionic strength. This is the first, structure that links the phosphorylation cascade of the two-component, systems with the antitermination event in the transcriptional machinery., Rv1626 belongs to a family of proteins, which we propose calling, phosphorylation-dependent transcriptional antitermination regulators, so, far only found in bacteria, and includes NasT, a protein from the, assimilatory nitrate/nitrite reductase operon of Azetobacter vinelandii.
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<StructureSection load='1sd5' size='340' side='right'caption='[[1sd5]], [[Resolution|resolution]] 1.68&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1sd5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SD5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SD5 FirstGlance]. <br>
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1SD5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv] with IOD as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SD5 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.68&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sd5 OCA], [https://pdbe.org/1sd5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sd5 RCSB], [https://www.ebi.ac.uk/pdbsum/1sd5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sd5 ProSAT], [https://www.topsan.org/Proteins/XMTB/1sd5 TOPSAN]</span></td></tr>
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The crystal and solution structure of a putative transcriptional antiterminator from Mycobacterium tuberculosis., Morth JP, Feng V, Perry LJ, Svergun DI, Tucker PA, Structure. 2004 Sep;12(9):1595-605. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15341725 15341725]
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</table>
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[[Category: Mycobacterium tuberculosis h37rv]]
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== Function ==
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[[Category: Single protein]]
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[https://www.uniprot.org/uniprot/PDTAR_MYCTU PDTAR_MYCTU] Member of the two-component regulatory system pdtaR/pdtaS.<ref>PMID:16026786</ref>
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[[Category: Feng, V.]]
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== Evolutionary Conservation ==
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[[Category: Morth, J.P.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Perry, L.J.]]
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Check<jmol>
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[[Category: Svergun, D.I.]]
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<jmolCheckbox>
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[[Category: TBSGC, TB.Structural.Genomics.Consortium.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sd/1sd5_consurf.spt"</scriptWhenChecked>
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[[Category: Tucker, P.A.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: IOD]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: antiterminator]]
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</jmolCheckbox>
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[[Category: protein structure initiative]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sd5 ConSurf].
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[[Category: psi]]
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<div style="clear:both"></div>
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[[Category: rv1626]]
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== References ==
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[[Category: structural genomics]]
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<references/>
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[[Category: tb structural genomics consortium]]
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__TOC__
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[[Category: tbsgc]]
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</StructureSection>
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[[Category: transcriptional]]
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[[Category: Large Structures]]
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[[Category: two components system]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Feng V]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:17:38 2007''
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[[Category: Morth JP]]
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[[Category: Perry LJ]]
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[[Category: Svergun DI]]
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[[Category: Tucker PA]]

Current revision

Crystal structure of Rv1626

PDB ID 1sd5

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