3gsr

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{{Seed}}
 
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[[Image:3gsr.jpg|left|200px]]
 
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==Crystal structure of the binary complex between HLA-A2 and HCMV NLV-M5V peptide variant==
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The line below this paragraph, containing "STRUCTURE_3gsr", creates the "Structure Box" on the page.
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<StructureSection load='3gsr' size='340' side='right'caption='[[3gsr]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3gsr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GSR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3gsn|3gsn]], [[3gso|3gso]], [[3gsq|3gsq]], [[3gsu|3gsu]], [[3gsv|3gsv]], [[3gsw|3gsw]], [[3gsx|3gsx]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HLA, HLA-A, HLAA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, Beta-2 microglubulin, CDABP0092, HDCMA22P ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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{{STRUCTURE_3gsr| PDB=3gsr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gsr OCA], [https://pdbe.org/3gsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gsr RCSB], [https://www.ebi.ac.uk/pdbsum/3gsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gsr ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[[https://www.uniprot.org/uniprot/1A02_HUMAN 1A02_HUMAN]] Involved in the presentation of foreign antigens to the immune system. [[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/3gsr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gsr ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Protective T cell responses elicited along chronic human CMV (HCMV) infections are sometimes dominated by CD8 T cell clones bearing highly related or identical public TCR in unrelated individuals. To understand the principles that guide emergence of these public T cell responses, we have performed structural, biophysical, and functional analyses of an immunodominant public TCR (RA14) directed against a major HLA-A*0201-restricted HCMV Ag (pp65(495-503)) and selected in vivo from a diverse repertoire after chronic stimulations. Unlike the two immunodominant public TCRs crystallized so far, which focused on one peptide hotspot, the HCMV-specific RA14 TCR interacts with the full array of available peptide residues. The conservation of some peptide-MHC complex-contacting amino acids by lower-affinity TCRs suggests a shared TCR-peptide-MHC complex docking mode and supports an Ag-driven selection of optimal TCRs. Therefore, the emergence of a public TCR of an oligoclonal Ag-specific response after repeated viral stimulations is based on a receptor displaying a high structural complementarity with the entire peptide and focusing on three peptide hotspots. This highlights key parameters underlying the selection of a protective T cell response against HCMV infection, which remains a major health issue in patients undergoing bone marrow transplantation.
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===Crystal structure of the binary complex between HLA-A2 and HCMV NLV-M5V peptide variant===
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Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope.,Gras S, Saulquin X, Reiser JB, Debeaupuis E, Echasserieau K, Kissenpfennig A, Legoux F, Chouquet A, Le Gorrec M, Machillot P, Neveu B, Thielens N, Malissen B, Bonneville M, Housset D J Immunol. 2009 Jul 1;183(1):430-7. PMID:19542454<ref>PMID:19542454</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3gsr" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19542454}}, adds the Publication Abstract to the page
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19542454 is the PubMed ID number.
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*[[MHC 3D structures|MHC 3D structures]]
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== References ==
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{{ABSTRACT_PUBMED_19542454}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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3GSR is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GSR OCA].
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[[Category: Human]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: Bonneville, M]]
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<ref group="xtra">PMID:19542454</ref><references group="xtra"/>
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[[Category: Chouquet, A]]
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[[Category: Homo sapiens]]
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[[Category: Debeaupuis, E]]
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[[Category: Bonneville, M.]]
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[[Category: Echasserieau, K]]
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[[Category: Chouquet, A.]]
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[[Category: Gorrec, M Le]]
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[[Category: Debeaupuis, E.]]
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[[Category: Gras, S]]
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[[Category: Echasserieau, K.]]
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[[Category: Housset, D]]
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[[Category: Gorrec, M Le.]]
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[[Category: Kissenpfennig, A]]
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[[Category: Gras, S.]]
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[[Category: Legoux, F]]
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[[Category: Housset, D.]]
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[[Category: Machillot, P]]
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[[Category: Kissenpfennig, A.]]
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[[Category: Malissen, B]]
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[[Category: Legoux, F.]]
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[[Category: Neveu, B]]
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[[Category: Machillot, P.]]
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[[Category: Reiser, J B]]
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[[Category: Malissen, B.]]
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[[Category: Saulquin, X]]
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[[Category: Neveu, B.]]
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[[Category: Thielens, N]]
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[[Category: Reiser, J B.]]
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[[Category: Saulquin, X.]]
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[[Category: Thielens, N.]]
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[[Category: Hla]]
[[Category: Hla]]
[[Category: Host-virus interaction]]
[[Category: Host-virus interaction]]
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[[Category: Public response]]
[[Category: Public response]]
[[Category: Restrained response]]
[[Category: Restrained response]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 5 10:17:52 2009''
 

Current revision

Crystal structure of the binary complex between HLA-A2 and HCMV NLV-M5V peptide variant

PDB ID 3gsr

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