This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2wp2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 2wp2 is ON HOLD Authors: Moriniere, J., Rousseaux, S., Steuerwald, U., Soler-Lopez, M., Curtet, S., Vitte, A.-L., Govin, J., Gaucher, J., Sadoul, K....)
Current revision (07:10, 1 May 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 2wp2 is ON HOLD
+
==Structure of Brdt bromodomain BD1 bound to a diacetylated histone H4 peptide.==
-
 
+
<StructureSection load='2wp2' size='340' side='right'caption='[[2wp2]], [[Resolution|resolution]] 2.37&Aring;' scene=''>
-
Authors: Moriniere, J., Rousseaux, S., Steuerwald, U., Soler-Lopez, M., Curtet, S., Vitte, A.-L., Govin, J., Gaucher, J., Sadoul, K., Hart, D.J., Krijgsveld, J., Khochbin, S., Mueller, C.W., Petosa, C.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[2wp2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WP2 FirstGlance]. <br>
-
Description: Structure of Brdt bromodomain BD1 bound to an acetylated histone H4 peptide.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALY:N(6)-ACETYLLYSINE'>ALY</scene></td></tr>
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 12 12:19:55 2009''
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wp2 OCA], [https://pdbe.org/2wp2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wp2 RCSB], [https://www.ebi.ac.uk/pdbsum/2wp2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wp2 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/BRDT_MOUSE BRDT_MOUSE] Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis. Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time. In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA. Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids. Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.<ref>PMID:12861021</ref> <ref>PMID:22901802</ref> <ref>PMID:22922464</ref> <ref>PMID:22570411</ref> <ref>PMID:19794495</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wp/2wp2_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wp2 ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Mus musculus]]
 +
[[Category: Curtet S]]
 +
[[Category: Gaucher J]]
 +
[[Category: Govin J]]
 +
[[Category: Hart DJ]]
 +
[[Category: Khochbin S]]
 +
[[Category: Krijgsveld J]]
 +
[[Category: Moriniere J]]
 +
[[Category: Mueller CW]]
 +
[[Category: Petosa C]]
 +
[[Category: Rousseaux S]]
 +
[[Category: Sadoul K]]
 +
[[Category: Soler-Lopez M]]
 +
[[Category: Steuerwald U]]
 +
[[Category: Vitte A-L]]

Current revision

Structure of Brdt bromodomain BD1 bound to a diacetylated histone H4 peptide.

PDB ID 2wp2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wp2"
Personal tools