2wb7

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{{Seed}}
 
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[[Image:2wb7.png|left|200px]]
 
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<!--
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==pT26-6p==
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The line below this paragraph, containing "STRUCTURE_2wb7", creates the "Structure Box" on the page.
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<StructureSection load='2wb7' size='340' side='right'caption='[[2wb7]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wb7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermococcus_sp._26-2 Thermococcus sp. 26-2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WB7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2wb6|2wb6]]</div></td></tr>
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{{STRUCTURE_2wb7| PDB=2wb7 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wb7 OCA], [https://pdbe.org/2wb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wb7 RCSB], [https://www.ebi.ac.uk/pdbsum/2wb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wb7 ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wb/2wb7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wb7 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We present here the 2.6A resolution crystal structure of the pT26-6p protein, which is encoded by an ORF of the plasmid pT26-2, recently isolated from the hyperthermophilic archaeon, Thermococcus sp. 26,2. This large protein is present in all members of a new family of mobile elements that, beside pT26-2 include several virus-like elements integrated in the genomes of several Thermococcales and Methanococcales (phylum Euryarchaeota). Phylogenetic analysis suggested that this protein, together with its nearest neighbor (organized as an operon) have coevolved for a long time with the cellular hosts of the encoding mobile element. As the sequences of the N and C-terminal regions suggested a possible membrane association, a deletion construct (739 amino acids) was used for structural analysis. The structure consists of two very similar beta-sheet domains with a new topology and a five helical bundle C-terminal domain. Each of these domains corresponds to a unique fold that has presently not been found in cellular proteins. This result supports the idea that proteins encoded by plasmid and viruses that have no cellular homologues could be a reservoir of new folds for structural genomic studies.
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===PT26-6P===
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A protein encoded by a new family of mobile elements from Euryarchaea exhibits three domains with novel folds.,Keller J, Leulliot N, Soler N, Collinet B, Vincentelli R, Forterre P, van Tilbeurgh H Protein Sci. 2009 Apr;18(4):850-5. PMID:19319959<ref>PMID:19319959</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19319959}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2wb7" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19319959 is the PubMed ID number.
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== References ==
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-->
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<references/>
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{{ABSTRACT_PUBMED_19319959}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2WB7 is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Archaea Archaea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WB7 OCA].
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[[Category: Thermococcus sp. 26-2]]
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[[Category: Collinet, B]]
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==Reference==
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[[Category: Forterre, P]]
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<ref group="xtra">PMID:19319959</ref><references group="xtra"/>
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[[Category: Keller, J]]
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[[Category: Archaea]]
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[[Category: Leulliot, N]]
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[[Category: Collinet, B.]]
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[[Category: Soler, N]]
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[[Category: Forterre, P.]]
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[[Category: Tilbeurgh, H van]]
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[[Category: Keller, J.]]
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[[Category: Vincentelli, R]]
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[[Category: Leulliot, N.]]
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[[Category: Soler, N.]]
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[[Category: Tilbeurgh, H Van.]]
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[[Category: Vincentelli, R.]]
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[[Category: Extra chromosomal element]]
[[Category: Extra chromosomal element]]
[[Category: Unknown function]]
[[Category: Unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 12 12:45:38 2009''
 

Current revision

pT26-6p

PDB ID 2wb7

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