3ii6

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{{Seed}}
 
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[[Image:3ii6.jpg|left|200px]]
 
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==Structure of human Xrcc4 in complex with the tandem BRCT domains of DNA LigaseIV.==
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The line below this paragraph, containing "STRUCTURE_3ii6", creates the "Structure Box" on the page.
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<StructureSection load='3ii6' size='340' side='right'caption='[[3ii6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ii6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3II6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3II6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_3ii6| PDB=3ii6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ii6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ii6 OCA], [https://pdbe.org/3ii6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ii6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ii6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ii6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/XRCC4_HUMAN XRCC4_HUMAN] Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.<ref>PMID:8548796</ref> <ref>PMID:10854421</ref> <ref>PMID:10757784</ref> <ref>PMID:16412978</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ii/3ii6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ii6 ConSurf].
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<div style="clear:both"></div>
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===Structure of human Xrcc4 in complex with the tandem BRCT domains of DNA LigaseIV.===
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==See Also==
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*[[DNA ligase 3D structures|DNA ligase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_19332554}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19332554 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_19332554}}
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==Disease==
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Known disease associated with this structure: LIG4 syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601837 601837]], Multiple myeloma, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601837 601837]]
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==About this Structure==
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3II6 is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3II6 OCA].
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==Reference==
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<ref group="xtra">PMID:19332554</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Junop, M.]]
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[[Category: Large Structures]]
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[[Category: Meesala, S.]]
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[[Category: Junop M]]
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[[Category: Alternative splicing]]
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[[Category: Meesala S]]
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[[Category: Atp-binding]]
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[[Category: Brct]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Coiled coil]]
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[[Category: Disease mutation]]
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[[Category: Dna damage]]
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[[Category: Dna ligase iv]]
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[[Category: Dna recombination]]
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[[Category: Dna repair]]
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[[Category: Dna replication]]
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[[Category: Isopeptide bond]]
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[[Category: Ligase]]
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[[Category: Ligase/dna binding protein complex]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Nhej]]
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[[Category: Nucleotide-binding]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Scid]]
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[[Category: Ubl conjugation]]
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[[Category: Xrcc4]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 12 13:49:35 2009''
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Current revision

Structure of human Xrcc4 in complex with the tandem BRCT domains of DNA LigaseIV.

PDB ID 3ii6

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Proteopedia Page Contributors and Editors (what is this?)

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