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2km1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of the N-terminal domain of the yeast protein Dre2== | |
| - | + | <StructureSection load='2km1' size='340' side='right'caption='[[2km1]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2km1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KM1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2km1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2km1 OCA], [https://pdbe.org/2km1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2km1 RCSB], [https://www.ebi.ac.uk/pdbsum/2km1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2km1 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DRE2_YEAST DRE2_YEAST] Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein TAH18. Has anti-apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death.[HAMAP-Rule:MF_03115]<ref>PMID:12759774</ref> <ref>PMID:18625724</ref> <ref>PMID:19194512</ref> <ref>PMID:20802492</ref> <ref>PMID:21902732</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/km/2km1_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2km1 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Baldacci G]] | ||
| + | [[Category: Craescu CT]] | ||
| + | [[Category: Delagoutte E]] | ||
| + | [[Category: Soler N]] | ||
| + | [[Category: Vernis-Beringue L]] | ||
Current revision
Solution structure of the N-terminal domain of the yeast protein Dre2
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