2kmj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:09, 27 November 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2kmj.jpg|left|200px]]
 
-
<!--
+
==High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry==
-
The line below this paragraph, containing "STRUCTURE_2kmj", creates the "Structure Box" on the page.
+
<StructureSection load='2kmj' size='340' side='right'caption='[[2kmj]]' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2kmj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_2 Human immunodeficiency virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KMJ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAR:D-ARGININE'>DAR</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=ZUK:5-PYRIMIDIN-2-YL-D-NORVALINE'>ZUK</scene></td></tr>
-
{{STRUCTURE_2kmj| PDB=2kmj | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kmj OCA], [https://pdbe.org/2kmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kmj RCSB], [https://www.ebi.ac.uk/pdbsum/2kmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kmj ProSAT]</span></td></tr>
 +
</table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Target TAR by NMR: Tripeptides containing arginines as terminal residues and non-natural amino acids as central residues are good leads for drug design to target the HIV trans-activation response element (TAR). The structural characterization of the RNA-ligand complex by NMR spectroscopy reveals two specific binding sites that are located at bulge residue U23 and around the pyrimidine-stretch U40-C41-U42 directly adjacent to the bulge.
-
===High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry===
+
Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.,Ferner J, Suhartono M, Breitung S, Jonker HR, Hennig M, Wohnert J, Gobel M, Schwalbe H Chembiochem. 2009 Jun 15;10(9):1490-4. PMID:19444830<ref>PMID:19444830</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_19444830}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 2kmj" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 19444830 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_19444830}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2KMJ is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_2 Human immunodeficiency virus 2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KMJ OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:19444830</ref><references group="xtra"/>
+
[[Category: Human immunodeficiency virus 2]]
[[Category: Human immunodeficiency virus 2]]
-
[[Category: Breitung, S.]]
+
[[Category: Large Structures]]
-
[[Category: Ferner, J.]]
+
[[Category: Breitung S]]
-
[[Category: Goebel, M.]]
+
[[Category: Ferner J]]
-
[[Category: Hennig, M.]]
+
[[Category: Goebel M]]
-
[[Category: Jonker, H R.]]
+
[[Category: Hennig M]]
-
[[Category: Schwalbe, H.]]
+
[[Category: Jonker HRA]]
-
[[Category: Suhartono, M.]]
+
[[Category: Schwalbe H]]
-
[[Category: Woehnert, J.]]
+
[[Category: Suhartono M]]
-
[[Category: Binding stoichiometry]]
+
[[Category: Woehnert J]]
-
[[Category: Hiv-2 tar]]
+
-
[[Category: Rna-ligand complex]]
+
-
[[Category: Rna/peptide complex]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 19 13:04:23 2009''
+

Current revision

High resolution NMR solution structure of a complex of HIV-2 TAR RNA and a synthetic tripeptide in a 1:2 stoichiometry

PDB ID 2kmj

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2kmj"
Personal tools