1k2j

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(New page: 200px<br /><applet load="1k2j" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k2j" /> '''NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)...)
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[[Image:1k2j.gif|left|200px]]<br /><applet load="1k2j" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1k2j" />
 
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'''NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)2'''<br />
 
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==Overview==
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==NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)2==
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Solution structures and base pair stacking of a self- complementary DNA, hexamer d(CGTACG)(2) have been studied at 5, 10 and 15 degrees C, respectively. The stacking interactions among the center base pair steps, of the DNA duplex are found to improve when the terminal base pairs became, less stable due to end fraying. A new structural quantity, the stacking, sum (Sigma(s)), is introduced to indicate small changes in the stacking, overlaps between base pairs. The improvements in the stacking overlaps to, maintain the double helical conformation are probably the cause for the, observed temperature dependent structural changes in double helical DNA, molecule. A detailed analysis of the helical parameters, backbone torsion, angles, base orientations and sugar conformations of these structures has, been performed.
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<StructureSection load='1k2j' size='340' side='right'caption='[[1k2j]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1k2j]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K2J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k2j OCA], [https://pdbe.org/1k2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k2j RCSB], [https://www.ebi.ac.uk/pdbsum/1k2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k2j ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Solution structures and base pair stacking of a self- complementary DNA hexamer d(CGTACG)(2) have been studied at 5, 10 and 15 degrees C, respectively. The stacking interactions among the center base pair steps of the DNA duplex are found to improve when the terminal base pairs became less stable due to end fraying. A new structural quantity, the stacking sum (Sigma(s)), is introduced to indicate small changes in the stacking overlaps between base pairs. The improvements in the stacking overlaps to maintain the double helical conformation are probably the cause for the observed temperature dependent structural changes in double helical DNA molecule. A detailed analysis of the helical parameters, backbone torsion angles, base orientations and sugar conformations of these structures has been performed.
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==About this Structure==
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Low temperature solution structures and base pair stacking of double helical d(CGTACG)(2).,Lam SL, Ip LN J Biomol Struct Dyn. 2002 Apr;19(5):907-17. PMID:11922844<ref>PMID:11922844</ref>
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1K2J is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1K2J OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Low temperature solution structures and base pair stacking of double helical d(CGTACG)(2)., Lam SL, Ip LN, J Biomol Struct Dyn. 2002 Apr;19(5):907-17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11922844 11922844]
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</div>
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[[Category: Protein complex]]
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<div class="pdbe-citations 1k2j" style="background-color:#fffaf0;"></div>
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[[Category: Ip, L.N.]]
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== References ==
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[[Category: Lam, S.L.]]
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<references/>
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[[Category: self-complementary dna]]
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__TOC__
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</StructureSection>
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:37:27 2007''
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[[Category: Large Structures]]
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[[Category: Ip LN]]
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[[Category: Lam SL]]

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NMR MINIMIZED AVERAGE STRUCTURE OF d(CGTACG)2

PDB ID 1k2j

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