1bw7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1bw7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bw7" /> '''SOLUTION STRUCTURE OF A DNA DUPLEX CONTAININ...)
Current revision (08:06, 10 April 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1bw7.jpg|left|200px]]<br /><applet load="1bw7" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1bw7" />
 
-
'''SOLUTION STRUCTURE OF A DNA DUPLEX CONTAINING A REPLICABLE DIFLUOROTOLUENE-ADENINE PAIR'''<br />
 
-
==Overview==
+
==SOLUTION STRUCTURE OF A DNA DUPLEX CONTAINING A REPLICABLE DIFLUOROTOLUENE-ADENINE PAIR==
-
A nonpolar aromatic nucleoside derivative based on 2,4-difluorotoluene, (F), a non-hydrogen bonding shape analog of thymidine, was recently shown, to be replicated against adenine with high efficiency and fidelity. This, led to the suggestion that geometric matching, potentially even in the, absence of hydrogen bonding between bases in a pair, may be sufficient to, direct nucleotide selection during replication. We have examined the, solution structure of the F-A pair in the context of a 12 base pair DNA, duplex. We find that, despite the destabilization caused by this analog, the F-A pair very closely resembles that of a T x A pair in the same, context. This lends support to the importance of shape matching in, replication.
+
<StructureSection load='1bw7' size='340' side='right'caption='[[1bw7]]' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1bw7]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BW7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BW7 FirstGlance]. <br>
-
1BW7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BW7 OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DFT:1-[2-DEOXYRIBOFURANOSYL]-2,4-DIFLUORO-5-METHYL-BENZENE-5MONOPHOSPHATE'>DFT</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bw7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bw7 OCA], [https://pdbe.org/1bw7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bw7 RCSB], [https://www.ebi.ac.uk/pdbsum/1bw7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bw7 ProSAT]</span></td></tr>
-
Solution structure of a DNA duplex containing a replicable difluorotoluene-adenine pair., Guckian KM, Krugh TR, Kool ET, Nat Struct Biol. 1998 Nov;5(11):954-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9808039 9808039]
+
</table>
-
[[Category: Protein complex]]
+
__TOC__
-
[[Category: Guckian, K.M.]]
+
</StructureSection>
-
[[Category: Kool, E.T.]]
+
[[Category: Large Structures]]
-
[[Category: Krugh, T.R.]]
+
[[Category: Guckian KM]]
-
[[Category: difluorotoluene]]
+
[[Category: Kool ET]]
-
[[Category: dna]]
+
[[Category: Krugh TR]]
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:41:06 2007''
+

Current revision

SOLUTION STRUCTURE OF A DNA DUPLEX CONTAINING A REPLICABLE DIFLUOROTOLUENE-ADENINE PAIR

PDB ID 1bw7

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bw7"
Personal tools