Ann Taylor sandbox 8

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== Adenosine Deaminase ==
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[[Image:3d06.jpg|left|200px]]
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<StructureSection load='2ada' size='350' side='right' caption='Structure of Adenosine Deaminase (PDB entry [[2ada]])' scene=''>
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{{STRUCTURE_3d06| PDB=3d06 | SCENE= }}
 
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===Human p53 core domain with hot spot mutation R249S (I)===
 
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===ADENOSINE DEAMINASE===
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{{ABSTRACT_PUBMED_18996393}}
 
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==Disease==
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Adenosine deaminase is involved in the degradation of purine nucleotides. It is especially active in lympocytes, and mutation of adenosine deaminase results in severe immunodeficiency. Adenosine deaminase contains an eight stranded parallel alpha/beta barrel with the active site in a deep pocket at the beta-barrel COOH-terminal end. <ref>PMID:1925539 </ref> The active site contains a <scene name='36/365336/Zinc_cofactor/2'>zinc cofactor</scene> which coordinates to the 6-hydroxyl of the transition state analogue, 6-hydroxyl, 1,6-dihydropurine ribonucleoside. The zinc is coordinated to three histidine residues and an aspartic acid residue.
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Known disease associated with this structure: Adrenal cortical carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Breast cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Colorectal cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Hepatocellular carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Histiocytoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Li-Fraumeni syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Multiple malignancy syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Nasopharyngeal carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Osteosarcoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Pancreatic cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]], Thyroid carcinoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=191170 191170]]
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==About this Structure==
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The transition state analogue held in place mostly by polar interactions. The ribose group is close to the opening of the pocket, with the purine portion deeper in the pocket, close to the zinc. Nine hydrogen bonds stabilize the transition state-enzyme complex.
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3D06 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3D06 OCA].
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==Reference==
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ADA is very stereoselective for the 6R isomer. This specificity is due to the location of the catalytic zinc, <scene name='36/365336/Asp295_residue/1'>Asp295</scene> and <scene name='36/365336/His_238/1'>His 238</scene>. Interestingly, one face of the purine ring is exposed to polar groups and zinc, while the other face is only exposed to nonpolar residues. The proposed catalytic mechanism has Asp295 act as a general base, while the zinc acts as an electrophile to activate the water molecule. His 238 orients the water and stabilizes the charge of the attacking hydroxide. The protonated <scene name='36/365336/Glutamic_acid_217/1'>Glu217</scene> or the water hydrogen bonded to it could donate or share a proton with the N1 of the substrate.
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<ref group="xtra">PMID:18996393</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Frolow, F.]]
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[[Category: Rozenberg, H.]]
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[[Category: Shakked, Z.]]
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[[Category: Shimon, L J.W.]]
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[[Category: Suad, O.]]
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[[Category: Acetylation]]
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[[Category: Activator]]
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[[Category: Alternative splicing]]
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[[Category: Anti-oncogene]]
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[[Category: Apoptosis]]
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[[Category: Cell cycle]]
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[[Category: Covalent protein-rna linkage]]
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[[Category: Cytoplasm]]
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[[Category: Disease mutation]]
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[[Category: Dna-binding]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Glycoprotein]]
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[[Category: Host-virus interaction]]
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[[Category: Li-fraumeni syndrome]]
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[[Category: Loop-sheet-helix motif]]
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[[Category: Metal-binding]]
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[[Category: Methylation]]
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[[Category: Mutant protein]]
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[[Category: Nucleus]]
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[[Category: P53]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Ubl conjugation]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 21 10:44:12 2009''
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<references/>
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</StructureSection>

Current revision

Adenosine Deaminase

Structure of Adenosine Deaminase (PDB entry 2ada)

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Proteopedia Page Contributors and Editors (what is this?)

William Guthrie, Chad Sorenson, Ann Taylor

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