3ips

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(New page: '''Unreleased structure''' The entry 3ips is ON HOLD Authors: Fradera, X., Vu, D., Nimz, O., Skene, R., Hosfield, D., Wijnands, R., Cooke, A.J., Haunso, A., King, A., Bennet, D.J., McGu...)
Current revision (10:06, 21 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3ips is ON HOLD
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==X-ray structure of benzisoxazole synthetic agonist bound to the LXR-alpha==
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<StructureSection load='3ips' size='340' side='right'caption='[[3ips]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ips]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IPS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O90:{3-CHLORO-4-[(3-{[7-PROPYL-3-(TRIFLUOROMETHYL)-1,2-BENZISOXAZOL-6-YL]OXY}PROPYL)SULFANYL]PHENYL}ACETIC+ACID'>O90</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ips FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ips OCA], [https://pdbe.org/3ips PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ips RCSB], [https://www.ebi.ac.uk/pdbsum/3ips PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ips ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NR1H3_HUMAN NR1H3_HUMAN] Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/3ips_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ips ConSurf].
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<div style="clear:both"></div>
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Authors: Fradera, X., Vu, D., Nimz, O., Skene, R., Hosfield, D., Wijnands, R., Cooke, A.J., Haunso, A., King, A., Bennet, D.J., McGuire, R., Uitdehaag, J.C.M.
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==See Also==
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*[[Liver X receptor|Liver X receptor]]
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Description: X-ray structure of synthetic agonist bound to the LXR-alpha LBD
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__TOC__
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</StructureSection>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 15:22:37 2009''
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Bennet DJ]]
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[[Category: Cooke AJ]]
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[[Category: Fradera X]]
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[[Category: Haunso A]]
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[[Category: Hosfield D]]
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[[Category: King A]]
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[[Category: McGuire R]]
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[[Category: Nimz O]]
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[[Category: Skene R]]
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[[Category: Uitdehaag JCM]]
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[[Category: Vu D]]
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[[Category: Wijnands R]]

Current revision

X-ray structure of benzisoxazole synthetic agonist bound to the LXR-alpha

PDB ID 3ips

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