2zvi

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[[Image:2zvi.jpg|left|200px]]
 
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==Crystal structure of 2,3-diketo-5-methylthiopentyl-1-phosphate enolase from Bacillus subtilis==
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The line below this paragraph, containing "STRUCTURE_2zvi", creates the "Structure Box" on the page.
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<StructureSection load='2zvi' size='340' side='right'caption='[[2zvi]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zvi]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZVI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zvi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvi OCA], [https://pdbe.org/2zvi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zvi RCSB], [https://www.ebi.ac.uk/pdbsum/2zvi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvi ProSAT]</span></td></tr>
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{{STRUCTURE_2zvi| PDB=2zvi | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTNW_BACSU MTNW_BACSU] Catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P).<ref>PMID:14551435</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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2,3-Diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1P enolase), a RuBisCO-like protein (RLP), catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate. The crystal structure of the apo decarbamylated form (E form) of Bacillus subtilis DK-MTP-1P enolase (Bs-DK-MTP-1P enolase) has been determined at 2.3 A resolution. The overall structure of the E form of Bs-DK-MTP-1P enolase highly resembles that of Geobacillus kaustophilus DK-MTP-1P enolase (Gk-DK-MTP-1P enolase), with the exception of a few insertions or deletions and of a few residues at the active site. In the E form of Bs-DK-MTP-1P enolase, Lys150 (equivalent to Lys175 in RuBisCO) at the active site adopts a conformation that is distinct from those observed in the other forms of Gk-DK-MTP-1P enolase. This unusual conformational change appears to be induced by changes in the varphi and psi angles of Gly151, which is conserved in the sequences of the Bs-DK-MTP-1P and Gk-DK-MTP-1P enolases but not in those of RuBisCOs. The loop at 303-312, equivalent to the catalytic loop termed ;loop-6' in RuBisCO, is in a closed conformation in the E form of Bs-DK-MTP-1P enolase. The closed conformation appears to be stabilized by Pro312, which is conserved in the sequences of several RLPs (equivalent to Glu338 in RuBisCO). Based on these results, the characteristic structural features of DK-MTP-1P enolase are discussed.
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===Crystal structure of 2,3-diketo-5-methylthiopentyl-1-phosphate enolase from Bacillus subtilis===
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Structure of the apo decarbamylated form of 2,3-diketo-5-methylthiopentyl-1-phosphate enolase from Bacillus subtilis.,Tamura H, Saito Y, Ashida H, Kai Y, Inoue T, Yokota A, Matsumura H Acta Crystallogr D Biol Crystallogr. 2009 Sep;65(Pt 9):942-51. Epub 2009, Aug 14. PMID:19690372<ref>PMID:19690372</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2zvi" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19690372}}, adds the Publication Abstract to the page
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*[[Enolase 3D structures|Enolase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19690372 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19690372}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2ZVI is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVI OCA].
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==Reference==
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<ref group="xtra">PMID:19690372</ref><references group="xtra"/>
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[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Inoue, T.]]
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[[Category: Large Structures]]
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[[Category: Kai, Y.]]
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[[Category: Inoue T]]
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[[Category: Matsumura, H.]]
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[[Category: Kai Y]]
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[[Category: Tamura, H.]]
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[[Category: Matsumura H]]
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[[Category: Yadani, T.]]
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[[Category: Tamura H]]
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[[Category: Amino-acid biosynthesis]]
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[[Category: Yadani T]]
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[[Category: Crystal structure]]
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[[Category: Enolase]]
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[[Category: Isomerase]]
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[[Category: Magnesium]]
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[[Category: Metal-binding]]
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[[Category: Methionine biosynthesis]]
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[[Category: Methionine salvage pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 15:35:22 2009''
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Current revision

Crystal structure of 2,3-diketo-5-methylthiopentyl-1-phosphate enolase from Bacillus subtilis

PDB ID 2zvi

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