3hag

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{{Seed}}
 
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[[Image:3hag.jpg|left|200px]]
 
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==Crystal structure of the Hepatitis E Virus-like Particle==
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The line below this paragraph, containing "STRUCTURE_3hag", creates the "Structure Box" on the page.
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<StructureSection load='3hag' size='340' side='right'caption='[[3hag]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3hag]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthohepevirus_A Orthohepevirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HAG FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hag OCA], [https://pdbe.org/3hag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hag RCSB], [https://www.ebi.ac.uk/pdbsum/3hag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hag ProSAT]</span></td></tr>
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{{STRUCTURE_3hag| PDB=3hag | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of the Hepatitis E Virus-like Particle===
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[https://www.uniprot.org/uniprot/CAPSD_HEVCT CAPSD_HEVCT] Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.[UniProtKB:Q9YLQ9] Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation (By similarity). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry. Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity). Inhibits IFN production by blocking host TBK1-induced IRF3 phosphorylation (By similarity). The nuclear form probably modulates host gene expression (By similarity).[UniProtKB:P29326][UniProtKB:P33426][UniProtKB:Q81871]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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The line below this paragraph, {{ABSTRACT_PUBMED_19622744}}, adds the Publication Abstract to the page
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[[Category: Orthohepevirus A]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19622744 is the PubMed ID number.
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[[Category: Guu TSY]]
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[[Category: Li K]]
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{{ABSTRACT_PUBMED_19622744}}
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[[Category: Liu Z]]
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[[Category: Mata DA]]
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==About this Structure==
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[[Category: Tao YJ]]
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3HAG is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_e_virus_type_4 Hepatitis e virus type 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAG OCA].
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[[Category: Ye Q]]
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[[Category: Yin C]]
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==Reference==
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[[Category: Zhang J]]
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<ref group="xtra">PMID:19622744</ref><references group="xtra"/>
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[[Category: Hepatitis e virus type 4]]
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[[Category: Guu, T S.Y.]]
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[[Category: Li, K.]]
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[[Category: Liu, Z.]]
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[[Category: Mata, D A.]]
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[[Category: Tao, Y J.]]
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[[Category: Ye, Q.]]
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[[Category: Yin, C.]]
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[[Category: Zhang, J.]]
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[[Category: Beta barrel]]
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[[Category: Icosahedral virus]]
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[[Category: Jelly-roll beta sheet]]
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[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 15:35:35 2009''
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Current revision

Crystal structure of the Hepatitis E Virus-like Particle

PDB ID 3hag

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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