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2k9f

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{{Seed}}
 
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[[Image:2k9f.png|left|200px]]
 
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==Structural features of the complex between the DsbD N-terminal and the PilB N-terminal domains from Neisseria meningitidis==
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The line below this paragraph, containing "STRUCTURE_2k9f", creates the "Structure Box" on the page.
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<StructureSection load='2k9f' size='340' side='right'caption='[[2k9f]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2k9f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neimd Neimd] and [https://en.wikipedia.org/wiki/Neimi Neimi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K9F FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2k0r|2k0r]], [[2jzs|2jzs]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">msrAB, pilB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=65699 NEIMD]), dsbD ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=491 NEIMI])</td></tr>
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{{STRUCTURE_2k9f| PDB=2k9f | SCENE= }}
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-disulfide_reductase Protein-disulfide reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.8 1.8.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k9f OCA], [https://pdbe.org/2k9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k9f RCSB], [https://www.ebi.ac.uk/pdbsum/2k9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k9f ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/MSRAB_NEIMA MSRAB_NEIMA]] Has an important function as a repair enzyme for proteins that have been inactivated by oxidation (By similarity). Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. [[https://www.uniprot.org/uniprot/DSBD_NEIMB DSBD_NEIMB]] Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/2k9f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k9f ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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DsbD transmembrane protein dispatches electrons to periplasmic Trx/DsbE-like partners via specific interactions with its N-terminal domain, nDsbD. In the present study, PilB N-terminal domain (NterPilB) is shown to efficiently accept electrons coming from nDsbD from Neisseria meningitidis. Using an NMR-driven docking approach, we have modeled the structure of a mixed disulfide complex between NterPilB and nDsbD. We show the needed opening of nDsbD cap-loop whereas NterPilB FLHE loop does not seem essential in the formation and stabilization of the complex. Relaxation analysis performed on backbone amide groups highlights a kind of dynamics transfer from nDsbD cap-loop on NterPilB alpha1 helix, suggesting that a mobility contribution is required not only for the formation of the mixed disulfide complex, but also for its disruption. Taking into account previous X-ray data on covalent complexes involving nDsbD, a cartoon of interactions between Trx-like partners and nDsbD is proposed that illustrates the adaptability of nDsbD.
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===Structural features of the complex between the DsbD N-terminal and the PilB N-terminal domains from Neisseria meningitidis===
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Formation of the complex between DsbD and PilB N-terminal domains from Neisseria meningitidis necessitates an adaptability of nDsbD.,Quinternet M, Tsan P, Selme-Roussel L, Jacob C, Boschi-Muller S, Branlant G, Cung MT Structure. 2009 Jul 15;17(7):1024-33. PMID:19604482<ref>PMID:19604482</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2k9f" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19604482}}, adds the Publication Abstract to the page
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*[[Thiol:disulfide interchange protein 3D structures|Thiol:disulfide interchange protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19604482 is the PubMed ID number.
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*[[Thioredoxin 3D structures|Thioredoxin 3D structures]]
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-->
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== References ==
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{{ABSTRACT_PUBMED_19604482}}
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<references/>
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__TOC__
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==About this Structure==
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</StructureSection>
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2K9F is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_a Neisseria meningitidis serogroup a] and [http://en.wikipedia.org/wiki/Neisseria_meningitidis_serogroup_b Neisseria meningitidis serogroup b]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K9F OCA].
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[[Category: Large Structures]]
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[[Category: Neimd]]
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==Reference==
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[[Category: Neimi]]
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<ref group="xtra">PMID:19604482</ref><references group="xtra"/>
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[[Category: Neisseria meningitidis serogroup a]]
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[[Category: Neisseria meningitidis serogroup b]]
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[[Category: Protein-disulfide reductase]]
[[Category: Protein-disulfide reductase]]
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[[Category: Boschi-Muller, S.]]
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[[Category: Boschi-Muller, S]]
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[[Category: Branlant, G.]]
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[[Category: Branlant, G]]
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[[Category: Cung, M.]]
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[[Category: Cung, M]]
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[[Category: Jacob, C.]]
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[[Category: Jacob, C]]
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[[Category: Quinternet, M.]]
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[[Category: Quinternet, M]]
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[[Category: Selme, L.]]
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[[Category: Selme, L]]
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[[Category: Tsan, P.]]
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[[Category: Tsan, P]]
[[Category: Cytochrome c-type biogenesis]]
[[Category: Cytochrome c-type biogenesis]]
[[Category: Docking]]
[[Category: Docking]]
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[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Transport]]
[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 15:59:40 2009''
 

Current revision

Structural features of the complex between the DsbD N-terminal and the PilB N-terminal domains from Neisseria meningitidis

PDB ID 2k9f

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