1sny

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(New page: 200px<br /><applet load="1sny" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sny, resolution 1.75&Aring;" /> '''Carbonyl reductase S...)
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[[Image:1sny.gif|left|200px]]<br /><applet load="1sny" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1sny, resolution 1.75&Aring;" />
 
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'''Carbonyl reductase Sniffer of D. melanogaster'''<br />
 
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==Overview==
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==Carbonyl reductase Sniffer of D. melanogaster==
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In vivo studies with the fruit-fly Drosophila melanogaster have shown that, the Sniffer protein prevents age-dependent and oxidative stress-induced, neurodegenerative processes. Sniffer is a NADPH-dependent carbonyl, reductase belonging to the enzyme family of short-chain, dehydrogenases/reductases (SDRs). The crystal structure of the homodimeric, Sniffer protein from Drosophila melanogaster in complex with NADP+ has, been determined by multiple-wavelength anomalous dispersion and refined to, a resolution of 1.75 A. The observed fold represents a typical, dinucleotide-binding domain as detected for other SDRs. With respect to, the cofactor-binding site and the region referred to as substrate-binding, loop, the Sniffer protein shows a striking similarity to the porcine, carbonyl reductase (PTCR). This loop, in both Sniffer and PTCR, is, substantially shortened compared to other SDRs. In most enzymes of the SDR, family this loop adopts a well-defined conformation only after substrate, binding and remains disordered in the absence of any bound ligands or even, if only the dinucleotide cofactor is bound. In the structure of the, Sniffer protein, however, the conformation of this loop is well defined, although no substrate is present. Molecular modeling studies provide an, idea of how binding of substrate molecules to Sniffer could possibly, occur.
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<StructureSection load='1sny' size='340' side='right'caption='[[1sny]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1sny]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SNY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SNY FirstGlance]. <br>
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1SNY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] with NAP as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SNY OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sny FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sny OCA], [https://pdbe.org/1sny PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sny RCSB], [https://www.ebi.ac.uk/pdbsum/1sny PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sny ProSAT]</span></td></tr>
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Structural insights into the neuroprotective-acting carbonyl reductase Sniffer of Drosophila melanogaster., Sgraja T, Ulschmid J, Becker K, Schneuwly S, Klebe G, Reuter K, Heine A, J Mol Biol. 2004 Oct 1;342(5):1613-24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15364585 15364585]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9W3H4_DROME Q9W3H4_DROME]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sn/1sny_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sny ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Becker, K.]]
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[[Category: Becker K]]
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[[Category: Heine, A.]]
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[[Category: Heine A]]
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[[Category: Klebe, G.]]
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[[Category: Klebe G]]
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[[Category: Reuter, K.]]
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[[Category: Reuter K]]
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[[Category: Schneuwly, S.]]
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[[Category: Schneuwly S]]
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[[Category: Sgraja, T.]]
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[[Category: Sgraja T]]
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[[Category: Ulschmid, J.]]
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[[Category: Ulschmid J]]
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[[Category: NAP]]
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[[Category: alpha and beta protein]]
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[[Category: dinucleotide binding motif]]
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[[Category: rossmann fold]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:52:37 2007''
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Current revision

Carbonyl reductase Sniffer of D. melanogaster

PDB ID 1sny

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