3hd6

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{{Seed}}
 
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[[Image:3hd6.jpg|left|200px]]
 
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==Crystal Structure of the Human Rhesus Glycoprotein RhCG==
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The line below this paragraph, containing "STRUCTURE_3hd6", creates the "Structure Box" on the page.
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<StructureSection load='3hd6' size='340' side='right'caption='[[3hd6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3hd6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HD6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene></td></tr>
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{{STRUCTURE_3hd6| PDB=3hd6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hd6 OCA], [https://pdbe.org/3hd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hd6 RCSB], [https://www.ebi.ac.uk/pdbsum/3hd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hd6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RHCG_HUMAN RHCG_HUMAN] Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.<ref>PMID:11062476</ref> <ref>PMID:14761968</ref> <ref>PMID:15929723</ref> <ref>PMID:16477434</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hd/3hd6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hd6 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In humans, NH(3) transport across cell membranes is facilitated by the Rh (rhesus) family of proteins. Human Rh C glycoprotein (RhCG) forms a trimeric complex that plays an essential role in ammonia excretion and renal pH regulation. The X-ray crystallographic structure of human RhCG, determined at 2.1 A resolution, reveals the mechanism of ammonia transport. Each monomer contains 12 transmembrane helices, one more than in the bacterial homologs. Reconstituted into proteoliposomes, RhCG conducts NH(3) to raise internal pH. Models of the erythrocyte Rh complex based on our RhCG structure suggest that the erythrocytic Rh complex is composed of stochastically assembled heterotrimers of RhAG, RhD, and RhCE.
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===Crystal Structure of the Human Rhesus Glycoprotein RhCG===
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Function of human Rh based on structure of RhCG at 2.1 A.,Gruswitz F, Chaudhary S, Ho JD, Schlessinger A, Pezeshki B, Ho CM, Sali A, Westhoff CM, Stroud RM Proc Natl Acad Sci U S A. 2010 May 25;107(21):9638-43. Epub 2010 May 10. PMID:20457942<ref>PMID:20457942</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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3HD6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HD6 OCA].
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<div class="pdbe-citations 3hd6" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: CSMP, Center for Structures of Membrane Proteins.]]
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[[Category: Large Structures]]
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[[Category: Chaudhary, S.]]
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[[Category: Chaudhary S]]
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[[Category: Gruswitz, F.]]
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[[Category: Gruswitz F]]
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[[Category: Ho, C-.M.]]
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[[Category: Ho C-M]]
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[[Category: Ho, J D.]]
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[[Category: Ho JD]]
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[[Category: Pezeshki, B.]]
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[[Category: Pezeshki B]]
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[[Category: Stroud, R M.]]
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[[Category: Stroud RM]]
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[[Category: Ammonia]]
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[[Category: Ammonia transport]]
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[[Category: Cell membrane]]
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[[Category: Center for structures of membrane protein]]
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[[Category: Channel]]
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[[Category: Csmp]]
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[[Category: Glycoprotein]]
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[[Category: Membrane]]
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[[Category: Membrane protein]]
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[[Category: Polymorphism]]
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[[Category: Protein structure initiative]]
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[[Category: Psi-2]]
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[[Category: Rhesus]]
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[[Category: Structural genomic]]
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[[Category: Transmembrane]]
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[[Category: Transport]]
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[[Category: Transport protein]]
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[[Category: Transporter]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 16:11:56 2009''
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Current revision

Crystal Structure of the Human Rhesus Glycoprotein RhCG

PDB ID 3hd6

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