This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3fnv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:50, 21 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3fnv.png|left|200px]]
 
-
<!--
+
==Crystal Structure of Miner1: The Redox-active 2Fe-2S Protein Causative in Wolfram Syndrome 2==
-
The line below this paragraph, containing "STRUCTURE_3fnv", creates the "Structure Box" on the page.
+
<StructureSection load='3fnv' size='340' side='right'caption='[[3fnv]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3fnv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FNV FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene></td></tr>
-
{{STRUCTURE_3fnv| PDB=3fnv | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fnv OCA], [https://pdbe.org/3fnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fnv RCSB], [https://www.ebi.ac.uk/pdbsum/3fnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fnv ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal Structure of Miner1: The Redox-active 2Fe-2S Protein Causative in Wolfram Syndrome 2===
+
== Disease ==
-
 
+
[https://www.uniprot.org/uniprot/CISD2_HUMAN CISD2_HUMAN] Defects in CISD2 are the cause of Wolfram syndrome type 2 (WFS2) [MIM:[https://omim.org/entry/604928 604928]. A rare disorder characterized by juvenile-onset insulin-dependent diabetes mellitus with optic atrophy. Other manifestations include diabetes insipidus, sensorineural deafness, dementia, psychiatric illnesses. WFS2 patients additionally show a strong bleeding tendency and gastrointestinal ulceration. Diabetes insipidus may be absent.<ref>PMID:17846994</ref>
-
 
+
== Function ==
-
<!--
+
[https://www.uniprot.org/uniprot/CISD2_HUMAN CISD2_HUMAN] Regulator of autophagy that contributes to antagonize BECN1-mediated cellular autophagy at the endoplasmic reticulum. Participates in the interaction of BCL2 with BECN1 and is required for BCL2-mediated depression of endoplasmic reticulum Ca(2+) stores during autophagy. Contributes to BIK-initiated autophagy, while it is not involved in BIK-dependent activation of caspases. Involved in life span control, probably via its function as regulator of autophagy.<ref>PMID:17846994</ref> <ref>PMID:20010695</ref>
-
The line below this paragraph, {{ABSTRACT_PUBMED_19580816}}, adds the Publication Abstract to the page
+
== Evolutionary Conservation ==
-
(as it appears on PubMed at http://www.pubmed.gov), where 19580816 is the PubMed ID number.
+
[[Image:Consurf_key_small.gif|200px|right]]
-
-->
+
Check<jmol>
-
{{ABSTRACT_PUBMED_19580816}}
+
<jmolCheckbox>
-
 
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/3fnv_consurf.spt"</scriptWhenChecked>
-
==About this Structure==
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
3FNV is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FNV OCA].
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==Reference==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3fnv ConSurf].
-
<ref group="xtra">PMID:19580816</ref><references group="xtra"/>
+
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Abresch, E C.]]
+
[[Category: Large Structures]]
-
[[Category: Axelrod, H L.]]
+
[[Category: Abresch EC]]
-
[[Category: Cohen, A E.]]
+
[[Category: Axelrod HL]]
-
[[Category: Conlan, A R.]]
+
[[Category: Cohen AE]]
-
[[Category: Jennings, P A.]]
+
[[Category: Conlan AR]]
-
[[Category: Nechushtai, R.]]
+
[[Category: Jennings PA]]
-
[[Category: Paddock, M L.]]
+
[[Category: Nechushtai R]]
-
[[Category: Yee, D.]]
+
[[Category: Paddock ML]]
-
[[Category: Zuris, J.]]
+
[[Category: Yee D]]
-
[[Category: 2fe-2]]
+
[[Category: Zuris J]]
-
[[Category: Acetylation]]
+
-
[[Category: Cdgsh]]
+
-
[[Category: Diabetes]]
+
-
[[Category: Endoplasmic reticulum]]
+
-
[[Category: Iron]]
+
-
[[Category: Iron-sulfur]]
+
-
[[Category: Membrane]]
+
-
[[Category: Membrane bound]]
+
-
[[Category: Metal binding protein]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Oxidative stress]]
+
-
[[Category: Thiazolidinedione]]
+
-
[[Category: Transmembrane]]
+
-
[[Category: Zinc]]
+
-
[[Category: Zinc-finger]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Sep 3 16:30:33 2009''
+

Current revision

Crystal Structure of Miner1: The Redox-active 2Fe-2S Protein Causative in Wolfram Syndrome 2

PDB ID 3fnv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3fnv"
Personal tools