This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1k9g

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="1k9g" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k9g, resolution 1.4&Aring;" /> '''Crystal Structure of ...)
Current revision (07:45, 7 February 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1k9g.gif|left|200px]]<br /><applet load="1k9g" size="450" color="white" frame="true" align="right" spinBox="true"
 
-
caption="1k9g, resolution 1.4&Aring;" />
 
-
'''Crystal Structure of the Complex of Cryptolepine-d(CCTAGG)2'''<br />
 
-
==Overview==
+
==Crystal Structure of the Complex of Cryptolepine-d(CCTAGG)2==
-
Cryptolepine, a naturally occurring indoloquinoline alkaloid used as an, antimalarial drug in Central and Western Africa, has been found to bind to, DNA in a formerly unknown intercalation mode. Evidence from competition, dialysis assays demonstrates that cryptolepine is able to bind CG-rich, sequences containing nonalternating CC sites. Here we show that, cryptolepine interacts with the CC sites of the DNA fragment d(CCTAGG)(2), in a base-stacking intercalation mode. This is the first DNA intercalator, complex, from approximately 90 solved by X-ray crystallography, to bind a, nonalternating (pyrimidine-pyrimidine) DNA sequence. The asymmetry of the, drug induces a perfect stacking with the asymmetric site, allowing for the, stability of the complex in the absence of hydrogen bonding interactions., The crystal structure of this antimalarial drug-DNA complex provides, evidence for the first nonalternating intercalation and, as such, provides, a basis for the design of new anticancer or antimalarial drugs.
+
<StructureSection load='1k9g' size='340' side='right'caption='[[1k9g]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[1k9g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K9G FirstGlance]. <br>
-
1K9G is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with DR1 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1K9G OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DR1:5-METHYL-5H-INDOLO[3,2-B]QUINOLINE'>DR1</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k9g OCA], [https://pdbe.org/1k9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k9g RCSB], [https://www.ebi.ac.uk/pdbsum/1k9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k9g ProSAT]</span></td></tr>
-
The antimalarial and cytotoxic drug cryptolepine intercalates into DNA at cytosine-cytosine sites., Lisgarten JN, Coll M, Portugal J, Wright CW, Aymami J, Nat Struct Biol. 2002 Jan;9(1):57-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11731803 11731803]
+
</table>
-
[[Category: Protein complex]]
+
__TOC__
-
[[Category: Aymami, J.]]
+
</StructureSection>
-
[[Category: Coll, M.]]
+
[[Category: Large Structures]]
-
[[Category: Lisgarten, J.N.]]
+
[[Category: Aymami J]]
-
[[Category: Portugal, J.]]
+
[[Category: Coll M]]
-
[[Category: Wright, C.W.]]
+
[[Category: Lisgarten JN]]
-
[[Category: DR1]]
+
[[Category: Portugal J]]
-
[[Category: dna intercalator complex]]
+
[[Category: Wright CW]]
-
 
+
-
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 00:59:15 2007''
+

Current revision

Crystal Structure of the Complex of Cryptolepine-d(CCTAGG)2

PDB ID 1k9g

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1k9g"
Personal tools