3hym

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{{Seed}}
 
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[[Image:3hym.png|left|200px]]
 
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==Insights into Anaphase Promoting Complex TPR subdomain assembly from a CDC26-APC6 structure==
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The line below this paragraph, containing "STRUCTURE_3hym", creates the "Structure Box" on the page.
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<StructureSection load='3hym' size='340' side='right'caption='[[3hym]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3hym]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HYM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HYM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3hym| PDB=3hym | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hym FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hym OCA], [https://pdbe.org/3hym PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hym RCSB], [https://www.ebi.ac.uk/pdbsum/3hym PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hym ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/3hym_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hym ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The multisubunit anaphase promoting complex (APC) is an essential cell-cycle regulator. Although CDC26 is known to have a role in APC assembly, its molecular function has remained unclear. Biophysical, structural and genetic studies presented here reveal that CDC26 stabilizes the structure of APC6, a core TPR protein required for APC integrity. Notably, CDC26-APC6 association involves an intermolecular TPR mimic composed of one helix from each protein.
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===Insights into Anaphase Promoting Complex TPR subdomain assembly from a CDC26-APC6 structure===
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Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure.,Wang J, Dye BT, Rajashankar KR, Kurinov I, Schulman BA Nat Struct Mol Biol. 2009 Sep;16(9):987-9. Epub 2009 Aug 9. PMID:19668213<ref>PMID:19668213</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19668213}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3hym" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19668213 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19668213}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3HYM is a 12 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HYM OCA].
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==Reference==
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<ref group="xtra">PMID:19668213</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dye, B T.]]
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[[Category: Large Structures]]
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[[Category: Kurinov, I.]]
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[[Category: Dye BT]]
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[[Category: Rajashankar, K R.]]
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[[Category: Kurinov I]]
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[[Category: Schulman, B A.]]
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[[Category: Rajashankar KR]]
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[[Category: Wang, J.]]
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[[Category: Schulman BA]]
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[[Category: Alternative splicing]]
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[[Category: Wang J]]
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[[Category: Anaphase promoting complex]]
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[[Category: Apc]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Coiled coil]]
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[[Category: Cyclosome]]
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[[Category: E3]]
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[[Category: Ligase]]
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[[Category: Mitosis]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Tpr]]
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[[Category: Tpr repeat]]
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[[Category: Twinning]]
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[[Category: Ubiquitin]]
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[[Category: Ubiquitin ligase]]
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[[Category: Ubl conjugation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:26:14 2009''
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Current revision

Insights into Anaphase Promoting Complex TPR subdomain assembly from a CDC26-APC6 structure

PDB ID 3hym

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