3ftl

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{{Seed}}
 
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[[Image:3ftl.png|left|200px]]
 
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==NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form==
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The line below this paragraph, containing "STRUCTURE_3ftl", creates the "Structure Box" on the page.
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<StructureSection load='3ftl' size='340' side='right'caption='[[3ftl]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ftl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FTL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ftl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ftl OCA], [https://pdbe.org/3ftl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ftl RCSB], [https://www.ebi.ac.uk/pdbsum/3ftl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ftl ProSAT]</span></td></tr>
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{{STRUCTURE_3ftl| PDB=3ftl | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IAPP_HUMAN IAPP_HUMAN] Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In prion inheritance and transmission, strains are phenotypic variants encoded by protein 'conformations'. However, it is unclear how a protein conformation can be stable enough to endure transmission between cells or organisms. Here we describe new polymorphic crystal structures of segments of prion and other amyloid proteins, which offer two structural mechanisms for the encoding of prion strains. In packing polymorphism, prion strains are encoded by alternative packing arrangements (polymorphs) of beta-sheets formed by the same segment of a protein; in segmental polymorphism, prion strains are encoded by distinct beta-sheets built from different segments of a protein. Both forms of polymorphism can produce enduring conformations capable of encoding strains. These molecular mechanisms for transfer of protein-encoded information into prion strains share features with the familiar mechanism for transfer of nucleic acid-encoded information into microbial strains, including sequence specificity and recognition by noncovalent bonds.
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===NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form===
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Molecular mechanisms for protein-encoded inheritance.,Wiltzius JJ, Landau M, Nelson R, Sawaya MR, Apostol MI, Goldschmidt L, Soriaga AB, Cascio D, Rajashankar K, Eisenberg D Nat Struct Mol Biol. 2009 Sep;16(9):973-8. Epub 2009 Aug 16. PMID:19684598<ref>PMID:19684598</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19684598}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3ftl" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19684598 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19684598}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Homo sapiens]]
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3FTL is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FTL OCA].
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[[Category: Large Structures]]
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[[Category: Eisenberg D]]
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==Reference==
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[[Category: Sawaya MR]]
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<ref group="xtra">PMID:19684598</ref><references group="xtra"/>
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[[Category: Wiltzius JJW]]
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[[Category: Eisenberg, D.]]
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[[Category: Sawaya, M R.]]
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[[Category: Wiltzius, J J.W.]]
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[[Category: Amyloid-like protofibril]]
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[[Category: Membrane protein]]
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[[Category: Protein fibril]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:33:39 2009''
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Current revision

NVGSNTY segment from Islet Amyloid Polypeptide (IAPP or Amylin), dehydrated crystal form

PDB ID 3ftl

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