3fva

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{{Seed}}
 
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[[Image:3fva.png|left|200px]]
 
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==NNQNTF segment from elk prion==
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The line below this paragraph, containing "STRUCTURE_3fva", creates the "Structure Box" on the page.
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<StructureSection load='3fva' size='340' side='right'caption='[[3fva]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3fva]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cervus_canadensis_nelsoni Cervus canadensis nelsoni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FVA FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.458&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fva FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fva OCA], [https://pdbe.org/3fva PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fva RCSB], [https://www.ebi.ac.uk/pdbsum/3fva PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fva ProSAT]</span></td></tr>
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{{STRUCTURE_3fva| PDB=3fva | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PRIO_CEREN PRIO_CEREN] Note=PrP is found in high quantity in the brain of humans and animals infected with the degenerative neurological diseases kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
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== Function ==
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[https://www.uniprot.org/uniprot/PRIO_CEREN PRIO_CEREN] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity).
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===NNQNTF segment from elk prion===
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==See Also==
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*[[Prion 3D structures|Prion 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Cervus canadensis nelsoni]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19684598 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Apostol MI]]
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{{ABSTRACT_PUBMED_19684598}}
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[[Category: Eisenberg D]]
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==About this Structure==
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3FVA is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FVA OCA].
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==Reference==
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<ref group="xtra">PMID:19684598</ref><references group="xtra"/>
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[[Category: Apostol, M I.]]
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[[Category: Eisenberg, D.]]
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[[Category: Amyloid-like protofibril]]
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[[Category: Cell membrane]]
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[[Category: Glycoprotein]]
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[[Category: Golgi apparatus]]
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[[Category: Gpi-anchor]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Prion]]
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[[Category: Protein fibril]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:35:29 2009''
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Current revision

NNQNTF segment from elk prion

PDB ID 3fva

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