3ipr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:55, 6 September 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3ipr.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of the Enterococcus faecalis gluconate specific EIIA phosphotransferase system component==
-
The line below this paragraph, containing "STRUCTURE_3ipr", creates the "Structure Box" on the page.
+
<StructureSection load='3ipr' size='340' side='right'caption='[[3ipr]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3ipr]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IPR FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-
{{STRUCTURE_3ipr| PDB=3ipr | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ipr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ipr OCA], [https://pdbe.org/3ipr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ipr RCSB], [https://www.ebi.ac.uk/pdbsum/3ipr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ipr ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/Q82ZC8_ENTFA Q82ZC8_ENTFA]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ip/3ipr_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ipr ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
In Eubacteria, the utilization of a number of extracellular carbohydrates is mediated by sugar specific phosphoenolepyruvate (PEP) dependent sugar phosphotransferase systems (PTSs), which simultaneously import und phosphorylate their target sugars. Here, we report the crystal structure of the EIIA(gnt) component of the so far little investigated Enterococcus faecalis gluconate specific PTS. The crystal structure shows a tightly interacting dimer of EIIA(gnt) which is structurally similar to the related EIIA(man) from Escherichia coli. Homology modeling of E. faecalis HPr, EIIB(man) and their complexes with EIIA(man) suggests that despite moderate sequence identity between EIIA(man) and EIIA(gnt), the active sites closely match the situation observed in the E. coli system with His-9 of EIIA(gnt) being the likely phosphoryl group carrier. We therefore propose that the phosphoryl transfer reactions involving EIIA(gnt) proceed according to a mechanism analog to the one described for E. coli EIIA(man).
-
===Crystal structure of the Enterococcus faecalis gluconate specific EIIA phosphotransferase system component===
+
Structure of the Enterococcus faecalis EIIA(gnt) PTS component.,Reinelt S, Koch B, Hothorn M, Hengstenberg W, Welti S, Scheffzek K Biochem Biophys Res Commun. 2009 Oct 30;388(4):626-9. Epub 2009 Aug 13. PMID:19682976<ref>PMID:19682976</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3ipr" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_19682976}}, adds the Publication Abstract to the page
+
*[[Phosphotransferase 3D structures|Phosphotransferase 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 19682976 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_19682976}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
3IPR is a 6 chains structure of sequences from [http://en.wikipedia.org/wiki/Enterococcus_faecalis Enterococcus faecalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IPR OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:19682976</ref><references group="xtra"/>
+
[[Category: Enterococcus faecalis]]
[[Category: Enterococcus faecalis]]
-
[[Category: Reinelt, S.]]
+
[[Category: Large Structures]]
-
[[Category: Scheffzek, K.]]
+
[[Category: Reinelt S]]
-
[[Category: Welti, S.]]
+
[[Category: Scheffzek K]]
-
[[Category: 4 stranded parallel beta-sheet flanked by 3 alpha-helices on each side]]
+
[[Category: Welti S]]
-
[[Category: Transferase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 08:59:08 2009''
+

Current revision

Crystal structure of the Enterococcus faecalis gluconate specific EIIA phosphotransferase system component

PDB ID 3ipr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3ipr"
Personal tools