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3ghz

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{{Seed}}
 
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[[Image:3ghz.png|left|200px]]
 
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==2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Salmonella typhimurium==
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The line below this paragraph, containing "STRUCTURE_3ghz", creates the "Structure Box" on the page.
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<StructureSection load='3ghz' size='340' side='right'caption='[[3ghz]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ghz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GHZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GHZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
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{{STRUCTURE_3ghz| PDB=3ghz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ghz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ghz OCA], [https://pdbe.org/3ghz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ghz RCSB], [https://www.ebi.ac.uk/pdbsum/3ghz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ghz ProSAT], [https://www.topsan.org/Proteins/CSGID/3ghz TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ISPF_SALTY ISPF_SALTY] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).[HAMAP-Rule:MF_00107]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gh/3ghz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ghz ConSurf].
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<div style="clear:both"></div>
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===2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Salmonella typhimurium===
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==See Also==
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*[[MECDP synthase 3D structures|MECDP synthase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3GHZ is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GHZ OCA].
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[[Category: Large Structures]]
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[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
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[[Category: Anderson WF]]
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[[Category: Anderson, W F.]]
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[[Category: Gu M]]
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[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
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[[Category: Joachimiak A]]
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[[Category: Gu, M.]]
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[[Category: Osipiuk J]]
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[[Category: Joachimiak, A.]]
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[[Category: Peterson S]]
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[[Category: Osipiuk, J.]]
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[[Category: Peterson, J.]]
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[[Category: 2-c-methyl-d-erythritol 2]]
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[[Category: 4-cyclodiphosphate synthase]]
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[[Category: Center for structural genomics of infectious disease]]
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[[Category: Csgid]]
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[[Category: Idp01038]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Lyase]]
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[[Category: Metal-binding]]
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[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 16 20:05:45 2009''
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Current revision

2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase from Salmonella typhimurium

PDB ID 3ghz

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