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| - | == M2 Channel from Influenza A == | + | == Inhibition of the M2 Channel from Influenza A == |
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| - | Publication Abstract from PubMed: | |
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| - | The M2 protein from influenza A virus is a pH-activated proton channel that mediates acidification of the interior of viral particles entrapped in endosomes. M2 is the target of the anti-influenza drugs amantadine and rimantadine; recently, resistance to these drugs in humans, birds and pigs has reached more than 90% (ref. 1). Here we describe the crystal structure of the transmembrane-spanning region of the homotetrameric protein in the presence and absence of the channel-blocking drug amantadine. pH-dependent structural changes occur near a set of conserved His and Trp residues that are involved in proton gating. The drug-binding site is lined by residues that are mutated in amantadine-resistant viruses. Binding of amantadine physically occludes the pore, and might also perturb the pK(a) of the critical His residue. The structure provides a starting point for solving the problem of resistance to M2-channel blockers.
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| - | ''Structural basis for the function and inhibition of an influenza virus proton channel., Stouffer AL, Acharya R, Salom D, Levine AS, Di Costanzo L, Soto CS, Tereshko V, Nanda V, Stayrook S, DeGrado WF, Nature. 2008 Jan 31;451(7178):596-9. PMID:[http://www.ncbi.nlm.nih.gov/sites/entrez/18235504 18235504]''
| + | Sarah is creating a new page for this protein. :) |
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. | |
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| | + | == New Demo Page == |
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| - | <applet load='3bkd' size='300' frame='true' align='right' caption='Insert caption here' /> | |
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| - | References
| + | For demo help, I've started a new page for you about the [[User:Amy Kerzmann/Sandbox 3| Voltage-Gated Potassium Channel]]. |
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| - | 1) Structural basis for the function and inhibition of an influenza virus proton channel., Stouffer AL, Acharya R, Salom D, Levine AS, Di Costanzo L, Soto CS, Tereshko V, Nanda V, Stayrook S, DeGrado WF, Nature. 2008 Jan 31;451(7178):596-9. PMID:[http://www.ncbi.nlm.nih.gov/sites/entrez/18235504 18235504]
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Current revision
Inhibition of the M2 Channel from Influenza A
Content removed!
Sarah is creating a new page for this protein. :)
New Demo Page
For demo help, I've started a new page for you about the Voltage-Gated Potassium Channel.
.
