2zt6

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{{Seed}}
 
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[[Image:2zt6.png|left|200px]]
 
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==Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with AMPCPP==
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The line below this paragraph, containing "STRUCTURE_2zt6", creates the "Structure Box" on the page.
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<StructureSection load='2zt6' size='340' side='right'caption='[[2zt6]], [[Resolution|resolution]] 3.08&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2zt6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZT6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZT6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.08&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APC:DIPHOSPHOMETHYLPHOSPHONIC+ACID+ADENOSYL+ESTER'>APC</scene></td></tr>
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{{STRUCTURE_2zt6| PDB=2zt6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zt6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zt6 OCA], [https://pdbe.org/2zt6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zt6 RCSB], [https://www.ebi.ac.uk/pdbsum/2zt6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zt6 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/GARS_HUMAN GARS_HUMAN] Autosomal dominant Charcot-Marie-Tooth disease type 2D;Distal hereditary motor neuropathy type 5. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/GARS_HUMAN GARS_HUMAN] Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:28675565, PubMed:24898252). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017).<ref>PMID:17544401</ref> <ref>PMID:19710017</ref> <ref>PMID:24898252</ref> <ref>PMID:28675565</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zt/2zt6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zt6 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with AMPCPP===
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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== References ==
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==Disease==
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<references/>
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Known disease associated with this structure: Charcot-Marie-Tooth disease, type 2D OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600287 600287]], Neuropathy, distal hereditary motor, type V OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=600287 600287]]
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__TOC__
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</StructureSection>
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==About this Structure==
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2ZT6 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZT6 OCA].
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[[Category: Glycine--tRNA ligase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Guo, R T.]]
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[[Category: Large Structures]]
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[[Category: Schimmel, P.]]
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[[Category: Guo RT]]
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[[Category: Yang, X L.]]
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[[Category: Schimmel P]]
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[[Category: Aminoacyl-trna synthetase]]
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[[Category: Yang XL]]
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[[Category: Ap4a]]
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[[Category: Atp]]
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[[Category: Atp-binding]]
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[[Category: Charcot-marie-tooth disease]]
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[[Category: Disease mutation]]
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[[Category: Gly-amp]]
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[[Category: Glycine]]
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[[Category: Ligase]]
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[[Category: Nucleotide-binding]]
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[[Category: Phosphoprotein]]
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[[Category: Protein biosynthesis]]
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[[Category: Trna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 16:41:46 2009''
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Current revision

Crystal structure of human Glycyl-tRNA synthetase (GlyRS) in complex with AMPCPP

PDB ID 2zt6

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