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1sz6
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1sz6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1sz6, resolution 2.05Å" /> '''MISTLETOE LECTIN I F...) |
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| - | [[Image:1sz6.gif|left|200px]]<br /><applet load="1sz6" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1sz6, resolution 2.05Å" /> | ||
| - | '''MISTLETOE LECTIN I FROM VISCUM ALBUM. CRYSTAL STRUCTURE AT 2.05 A RESOLUTION'''<br /> | ||
| - | == | + | ==MISTLETOE LECTIN I FROM VISCUM ALBUM. CRYSTAL STRUCTURE AT 2.05 A RESOLUTION== |
| - | + | <StructureSection load='1sz6' size='340' side='right'caption='[[1sz6]], [[Resolution|resolution]] 2.05Å' scene=''> | |
| - | [[Category: | + | == Structural highlights == |
| + | <table><tr><td colspan='2'>[[1sz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Viscum_album Viscum album]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SZ6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AZI:AZIDE+ION'>AZI</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sz6 OCA], [https://pdbe.org/1sz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sz6 RCSB], [https://www.ebi.ac.uk/pdbsum/1sz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sz6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ML1_VISAL ML1_VISAL] The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Inhibits growth of the human tumor cell line Molt4.<ref>PMID:15182350</ref> <ref>PMID:15001393</ref> <ref>PMID:1450445</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sz/1sz6_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sz6 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Viscum album]] | [[Category: Viscum album]] | ||
| - | [[Category: Betzel | + | [[Category: Betzel C]] |
| - | [[Category: Gabdoulkhakov | + | [[Category: Gabdoulkhakov AG]] |
| - | [[Category: Guhlistova | + | [[Category: Guhlistova NE]] |
| - | [[Category: Krauspenhaar | + | [[Category: Krauspenhaar R]] |
| - | [[Category: Lyashenko | + | [[Category: Lyashenko AV]] |
| - | [[Category: Mikhailov | + | [[Category: Mikhailov AM]] |
| - | [[Category: Nikonov | + | [[Category: Nikonov SV]] |
| - | [[Category: Stoeva | + | [[Category: Stoeva S]] |
| - | [[Category: Voelter | + | [[Category: Voelter W]] |
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Current revision
MISTLETOE LECTIN I FROM VISCUM ALBUM. CRYSTAL STRUCTURE AT 2.05 A RESOLUTION
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