2ztn

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{{Seed}}
 
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[[Image:2ztn.png|left|200px]]
 
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==Hepatitis E virus ORF2 (Genotype 3)==
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The line below this paragraph, containing "STRUCTURE_2ztn", creates the "Structure Box" on the page.
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<StructureSection load='2ztn' size='340' side='right'caption='[[2ztn]], [[Resolution|resolution]] 3.56&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ztn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthohepevirus_A Orthohepevirus A]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZTN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZTN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.56&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ztn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ztn OCA], [https://pdbe.org/2ztn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ztn RCSB], [https://www.ebi.ac.uk/pdbsum/2ztn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ztn ProSAT]</span></td></tr>
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{{STRUCTURE_2ztn| PDB=2ztn | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPSD_HEVUS CAPSD_HEVUS] Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.<ref>PMID:29669922</ref> Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation (By similarity). Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry. Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes (By similarity). Inhibits IFN production by blocking host TBK1-induced IRF3 phosphorylation (By similarity). The nuclear form probably modulates host gene expression (By similarity).[UniProtKB:P29326][UniProtKB:P33426][UniProtKB:Q81871]
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===Hepatitis E virus ORF2 (Genotype 3)===
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 19620712 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_19620712}}
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[[Category: Orthohepevirus A]]
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[[Category: Li TC]]
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==About this Structure==
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[[Category: Matsuura Y]]
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2ZTN is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_e_virus Hepatitis e virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZTN OCA].
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[[Category: Mori Y]]
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[[Category: Takeda N]]
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==Reference==
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[[Category: Unno H]]
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<ref group="xtra">PMID:19620712</ref><references group="xtra"/>
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[[Category: Yamashita T]]
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[[Category: Hepatitis e virus]]
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[[Category: Li, T C.]]
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[[Category: Matsuura, Y.]]
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[[Category: Mori, Y.]]
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[[Category: Takeda, N.]]
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[[Category: Unno, H.]]
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[[Category: Yamashita, T.]]
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[[Category: Hev]]
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[[Category: Virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 19:22:42 2009''
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Current revision

Hepatitis E virus ORF2 (Genotype 3)

PDB ID 2ztn

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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