3f1j

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{{Seed}}
 
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[[Image:3f1j.png|left|200px]]
 
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==Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals RNA binding properties==
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The line below this paragraph, containing "STRUCTURE_3f1j", creates the "Structure Box" on the page.
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<StructureSection load='3f1j' size='340' side='right'caption='[[3f1j]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3f1j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borna_disease_virus Borna disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F1J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F1J FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C5P:CYTIDINE-5-MONOPHOSPHATE'>C5P</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3f1j| PDB=3f1j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f1j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f1j OCA], [https://pdbe.org/3f1j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f1j RCSB], [https://www.ebi.ac.uk/pdbsum/3f1j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f1j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MATRX_BDV1 MATRX_BDV1] Plays a crucial role in virion assembly and budding.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f1/3f1j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f1j ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Borna disease virus (BDV) is a neurotropic enveloped RNA virus that causes a noncytolytic, persistent infection of the central nervous system in mammals. BDV belongs to the order Mononegavirales, which also includes the negative-strand RNA viruses (NSVs) Ebola, Marburg, vesicular stomatitis, rabies, mumps, and measles. BDV-M, the matrix protein (M-protein) of BDV, is the smallest M-protein (16.2 kDa) among the NSVs. M-proteins play a critical role in virus assembly and budding, mediating the interaction between the viral capsid, envelope, and glycoprotein spikes, and are as such responsible for the structural stability and individual form of virus particles. Here, we report the 3D structure of BDV-M, a full-length M-protein structure from a nonsegmented RNA NSV. The BDV-M monomer exhibits structural similarity to the N-terminal domain of the Ebola M-protein (VP40), while the surface charge of the tetramer provides clues to the membrane association of BDV-M. Additional electron density in the crystal reveals the presence of bound nucleic acid, interpreted as cytidine-5'-monophosphate. The heterologously expressed BDV-M copurifies with and protects ssRNA oligonucleotides of a median length of 16 nt taken up from the expression host. The results presented here show that BDV-M would be able to bind RNA and lipid membranes simultaneously, expanding the repertoire of M-protein functionalities.
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===Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals RNA binding properties===
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Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals ssRNA binding properties.,Neumann P, Lieber D, Meyer S, Dautel P, Kerth A, Kraus I, Garten W, Stubbs MT Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3710-5. Epub 2009 Feb 23. PMID:19237566<ref>PMID:19237566</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19237566}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3f1j" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19237566 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19237566}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3F1J is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Borna_disease_virus Borna disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F1J OCA].
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==Reference==
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<ref group="xtra">PMID:19237566</ref><references group="xtra"/>
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[[Category: Borna disease virus]]
[[Category: Borna disease virus]]
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[[Category: Dautel, P.]]
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[[Category: Large Structures]]
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[[Category: Garten, W.]]
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[[Category: Dautel P]]
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[[Category: Kerth, A.]]
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[[Category: Garten W]]
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[[Category: Kraus, I.]]
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[[Category: Kerth A]]
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[[Category: Lieber, D.]]
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[[Category: Kraus I]]
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[[Category: Meyer, S.]]
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[[Category: Lieber D]]
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[[Category: Neumann, P.]]
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[[Category: Meyer S]]
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[[Category: Stubbs, M T.]]
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[[Category: Neumann P]]
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[[Category: Alternative splicing]]
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[[Category: Stubbs MT]]
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[[Category: Bornaviridae]]
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[[Category: Bornavirus]]
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[[Category: Cytoplasm]]
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[[Category: Membrane binding]]
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[[Category: Mononegavirale]]
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[[Category: Rna binding]]
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[[Category: Ssrna negative-strand viruse]]
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[[Category: Viral matrix protein]]
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[[Category: Viral protein]]
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[[Category: Virion]]
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[[Category: Viruse]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 20:13:44 2009''
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Current revision

Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals RNA binding properties

PDB ID 3f1j

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