3flg

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{{Seed}}
 
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[[Image:3flg.png|left|200px]]
 
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==The PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 beta==
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The line below this paragraph, containing "STRUCTURE_3flg", creates the "Structure Box" on the page.
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<StructureSection load='3flg' size='340' side='right'caption='[[3flg]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3flg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FLG FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3flg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3flg OCA], [https://pdbe.org/3flg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3flg RCSB], [https://www.ebi.ac.uk/pdbsum/3flg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3flg ProSAT]</span></td></tr>
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{{STRUCTURE_3flg| PDB=3flg | SCENE= }}
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN] ICF syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10647011</ref> <ref>PMID:10555141</ref> <ref>PMID:10588719</ref> <ref>PMID:11102980</ref> <ref>PMID:15580563</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/DNM3B_HUMAN DNM3B_HUMAN] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.<ref>PMID:16357870</ref> <ref>PMID:17303076</ref> <ref>PMID:18413740</ref> <ref>PMID:18567530</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fl/3flg_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3flg ConSurf].
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<div style="clear:both"></div>
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===The PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 beta===
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==See Also==
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*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
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== References ==
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==Disease==
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<references/>
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Known disease associated with this structure: Immunodeficiency-centromeric instability-facial anomalies syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602900 602900]]
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__TOC__
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</StructureSection>
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==About this Structure==
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3FLG is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FLG OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Amaya, M F.]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Amaya MF]]
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[[Category: Botchkarev, A.]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M.]]
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[[Category: Botchkarev A]]
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[[Category: MacKenzie, F.]]
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[[Category: Edwards AM]]
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[[Category: Min, J.]]
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[[Category: MacKenzie F]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Min J]]
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[[Category: Sundstrom, M.]]
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[[Category: Sundstrom M]]
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[[Category: Weigelt, J.]]
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[[Category: Weigelt J]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Zeng, H.]]
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[[Category: Zeng H]]
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[[Category: Alternative splicing]]
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[[Category: Disease mutation]]
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[[Category: Dna-binding]]
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[[Category: Dnmt3b]]
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[[Category: Metal-binding]]
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[[Category: Methyltransferase]]
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[[Category: Methyltransferase 3 beta]]
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[[Category: Nucleus]]
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[[Category: Polymorphism]]
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[[Category: Pwwp domain]]
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[[Category: S-adenosyl-l-methionine]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Transferase]]
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[[Category: Ubl conjugation]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 20:15:17 2009''
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Current revision

The PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 beta

PDB ID 3flg

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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