3haj

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{{Seed}}
 
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[[Image:3haj.png|left|200px]]
 
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==Crystal structure of human PACSIN2 F-BAR domain (p212121 lattice)==
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The line below this paragraph, containing "STRUCTURE_3haj", creates the "Structure Box" on the page.
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<StructureSection load='3haj' size='340' side='right'caption='[[3haj]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3haj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HAJ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_3haj| PDB=3haj | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3haj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3haj OCA], [https://pdbe.org/3haj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3haj RCSB], [https://www.ebi.ac.uk/pdbsum/3haj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3haj ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PACN2_HUMAN PACN2_HUMAN] May play a role in endocytosis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/3haj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3haj ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Peripheral membrane proteins of the Bin/amphiphysin/Rvs (BAR) and Fer-CIP4 homology-BAR (F-BAR) family participate in cellular membrane trafficking and have been shown to generate membrane tubules. The degree of membrane bending appears to be encoded in the structure and immanent curvature of the particular protein domains, with BAR and F-BAR domains inducing high- and low-curvature tubules, respectively. In addition, oligomerization and the formation of ordered arrays influences tubule stabilization. Here, the F-BAR domain-containing protein Pacsin was found to possess a unique activity, creating small tubules and tubule constrictions, in addition to the wide tubules characteristic for this subfamily. Based on crystal structures of the F-BAR domain of Pacsin and mutagenesis studies, vesiculation could be linked to the presence of unique structural features distinguishing it from other F-BAR proteins. Tubulation was suppressed in the context of the full-length protein, suggesting that Pacsin is autoinhibited in solution. The regulated deformation of membranes and promotion of tubule constrictions by Pacsin suggests a more versatile function of these proteins in vesiculation and endocytosis beyond their role as scaffold proteins.
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===Crystal structure of human PACSIN2 F-BAR domain (p212121 lattice)===
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Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin.,Wang Q, Navarro MV, Peng G, Molinelli E, Lin Goh S, Judson BL, Rajashankar KR, Sondermann H Proc Natl Acad Sci U S A. 2009 Jun 24. PMID:19549836<ref>PMID:19549836</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_19549836}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 3haj" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 19549836 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19549836}}
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__TOC__
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</StructureSection>
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==About this Structure==
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3HAJ is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HAJ OCA].
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==Reference==
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<ref group="xtra">PMID:19549836</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Navarro, M V.A S.]]
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[[Category: Large Structures]]
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[[Category: Peng, G.]]
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[[Category: Navarro MVAS]]
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[[Category: Rajashankar, K R.]]
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[[Category: Peng G]]
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[[Category: Sondermann, H.]]
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[[Category: Rajashankar KR]]
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[[Category: Wang, Q.]]
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[[Category: Sondermann H]]
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[[Category: Alternative splicing]]
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[[Category: Wang Q]]
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[[Category: Coiled coil]]
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[[Category: Cytoplasmic vesicle]]
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[[Category: Endocytosis]]
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[[Category: F-bar]]
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[[Category: Fap52]]
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[[Category: Pacsin]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Sh3 domain]]
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[[Category: Syndapin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Sep 21 21:00:38 2009''
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Current revision

Crystal structure of human PACSIN2 F-BAR domain (p212121 lattice)

PDB ID 3haj

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