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1cgc

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(New page: 200px<br /><applet load="1cgc" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cgc, resolution 2.200&Aring;" /> '''DOUBLE HELIX CONFOR...)
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[[Image:1cgc.jpg|left|200px]]<br /><applet load="1cgc" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1cgc, resolution 2.200&Aring;" />
 
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'''DOUBLE HELIX CONFORMATION GROOVE DIMENSIONS AND LIGAND BINDING POTENTIAL OF A G/C-STRETCH IN B-DNA'''<br />
 
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==Overview==
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==DOUBLE HELIX CONFORMATION GROOVE DIMENSIONS AND LIGAND BINDING POTENTIAL OF A G/C-STRETCH IN B-DNA==
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The self-complementary DNA fragment CCGGCGCCGG crystallizes in the, rhombohedral space group R3 with unit cell parameters a = 54.07 A and c =, 44.59 A. The structure has been determined by X-ray diffraction methods at, 2.2 A resolution and refined to an R value of 16.7%. In the crystal, the, decamer forms B-DNA double helices with characteristic groove dimensions:, compared with B-DNA of random sequence, the minor groove is wide and deep, and the major groove is rather shallow. Local base pair geometries and, stacking patterns are within the range commonly observed in B-DNA crystal, structures. The duplex bears no resemblance to A-form DNA as might have, been expected for a sequence with only GC base pairs. The shallow major, groove permits an unusual crystal packing pattern with several direct, intermolecular hydrogen bonds between phosphate oxygens and cytosine amino, groups. In addition, decameric duplexes form quasi-infinite double helices, in the crystal by end-to-end stacking. The groove geometries and, accessibilities of this molecule as observed in the crystal may be, important for the mode of binding of both proteins and drug molecules to, G/C stretches in DNA.
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<StructureSection load='1cgc' size='340' side='right'caption='[[1cgc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1cgc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CGC FirstGlance]. <br>
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1CGC is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1CGC OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cgc OCA], [https://pdbe.org/1cgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cgc RCSB], [https://www.ebi.ac.uk/pdbsum/1cgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cgc ProSAT]</span></td></tr>
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==Reference==
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</table>
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Double helix conformation, groove dimensions and ligand binding potential of a G/C stretch in B-DNA., Heinemann U, Alings C, Bansal M, EMBO J. 1992 May;11(5):1931-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1582421 1582421]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Bansal, M.]]
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[[Category: Large Structures]]
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[[Category: Heinemann, U.]]
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[[Category: Bansal M]]
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[[Category: b-dna]]
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[[Category: Heinemann U]]
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[[Category: double helix]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 01:29:50 2007''
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Current revision

DOUBLE HELIX CONFORMATION GROOVE DIMENSIONS AND LIGAND BINDING POTENTIAL OF A G/C-STRETCH IN B-DNA

PDB ID 1cgc

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