2hyz

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{{Seed}}
 
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[[Image:2hyz.png|left|200px]]
 
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==Crystal structure of an 8 repeat consensus TPR superhelix (orthorombic crystal form)==
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The line below this paragraph, containing "STRUCTURE_2hyz", creates the "Structure Box" on the page.
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<StructureSection load='2hyz' size='340' side='right'caption='[[2hyz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hyz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HYZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HYZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SM:SAMARIUM+(III)+ION'>SM</scene></td></tr>
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{{STRUCTURE_2hyz| PDB=2hyz | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hyz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hyz OCA], [https://pdbe.org/2hyz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hyz RCSB], [https://www.ebi.ac.uk/pdbsum/2hyz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hyz ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hy/2hyz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hyz ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure and stability of repeat proteins has been little studied in comparison to the properties of the more familiar globular proteins. Here, the structure and stability of designed tetratricopeptide-repeat (TPR) proteins is described. The TPR is a 34-amino-acid motif which adopts a helix-turn-helix structure and occurs as tandem repeats. The design of a consensus TPR motif (CTPR) has previously been described. Here, the crystal structures and stabilities of proteins that contain eight or 20 identical tandem repeats of the CTPR motif (CTPR8 and CTPR20) are presented. Both CTPR8 and CTPR20 adopt a superhelical overall structure. The structures of the different-length CTPR proteins are compared with each other and with the structures of natural TPR domains. Also, the unusual and perhaps unique crystal-packing interactions resulting in pseudo-infinite crystalline superhelices observed in the different crystal forms of CTPR8 and CTPR20 are discussed. Finally, it is shown that the thermodynamic behavior of CTPR8 and CTPR20 can be predicted from the behavior of other TPRs in this series using an Ising model-based analysis. The designed protein series CTPR2-CTPR20 covers the natural size repertoire of TPR domains and as such is an excellent model system for natural TPR proteins.
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===Crystal structure of an 8 repeat consensus TPR superhelix (orthorombic crystal form)===
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Structure and stability of designed TPR protein superhelices: unusual crystal packing and implications for natural TPR proteins.,Kajander T, Cortajarena AL, Mochrie S, Regan L Acta Crystallogr D Biol Crystallogr. 2007 Jul;63(Pt 7):800-11. Epub 2007, Jun 15. PMID:17582171<ref>PMID:17582171</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17582171}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2hyz" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17582171 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17582171}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2HYZ is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HYZ OCA].
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[[Category: Cortajarena AL]]
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[[Category: Kajander T]]
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==Reference==
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[[Category: Regan L]]
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<ref group="xtra">PMID:17582171</ref><references group="xtra"/>
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[[Category: Cortajarena, A L.]]
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[[Category: Kajander, T.]]
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[[Category: Regan, L.]]
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[[Category: De novo protein]]
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[[Category: Protein design]]
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[[Category: Protein stability]]
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[[Category: Superhelix]]
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[[Category: Tetratricopeptide]]
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[[Category: Tpr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 08:13:06 2009''
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Current revision

Crystal structure of an 8 repeat consensus TPR superhelix (orthorombic crystal form)

PDB ID 2hyz

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