2wo9

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{{Seed}}
 
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[[Image:2wo9.png|left|200px]]
 
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==MMP12 complex with a beta hydroxy carboxylic acid==
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The line below this paragraph, containing "STRUCTURE_2wo9", creates the "Structure Box" on the page.
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<StructureSection load='2wo9' size='340' side='right'caption='[[2wo9]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2wo9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WO9 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=023:N^2^-[(2R)-2-{(1S)-1-[FORMYL(HYDROXY)AMINO]ETHYL}-5-PHENYLPENTANOYL]-N,3-DIMETHYL-L-VALINAMIDE'>023</scene>, <scene name='pdbligand=068:(3S)-5-(4-ACETYLBIPHENYL-4-YL)-3-HYDROXYPENTANOIC+ACID'>068</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2wo9| PDB=2wo9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wo9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wo9 OCA], [https://pdbe.org/2wo9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wo9 RCSB], [https://www.ebi.ac.uk/pdbsum/2wo9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wo9 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/2wo9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wo9 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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A new class of selective MMP-12 inhibitors have been identified via high throughput screening. Crystallization with MMP-12 confirmed the mode of binding and allowed initial optimization to be carried out using classical structure based design.
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===MMP12 COMPLEX WITH A BETA HYDROXY CARBOXYLIC ACID===
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The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors.,Holmes IP, Gaines S, Watson SP, Lorthioir O, Walker A, Baddeley SJ, Herbert S, Egan D, Convery MA, Singh OM, Gross JW, Strelow JM, Smith RH, Amour AJ, Brown D, Martin SL Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. Epub 2009 Aug 6. PMID:19703773<ref>PMID:19703773</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2wo9" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_19703773}}, adds the Publication Abstract to the page
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 19703773 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_19703773}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2WO9 is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WO9 OCA].
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==Reference==
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<ref group="xtra">PMID:19703773</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Macrophage elastase]]
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[[Category: Large Structures]]
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[[Category: Amour, A J.]]
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[[Category: Amour AJ]]
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[[Category: Baddeley, S J.]]
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[[Category: Baddeley SJ]]
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[[Category: Brown, D.]]
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[[Category: Brown D]]
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[[Category: Convery, M A.]]
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[[Category: Convery MA]]
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[[Category: Egan, D.]]
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[[Category: Egan D]]
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[[Category: Gaines, S.]]
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[[Category: Gaines S]]
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[[Category: Gross, J W.]]
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[[Category: Gross JW]]
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[[Category: Herbert, S.]]
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[[Category: Herbert S]]
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[[Category: Holmes, I P.]]
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[[Category: Holmes IP]]
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[[Category: Lorthioir, O.]]
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[[Category: Lorthioir O]]
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[[Category: Martin, S L.]]
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[[Category: Martin SL]]
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[[Category: Singh, O M.P.]]
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[[Category: Singh OMP]]
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[[Category: Smith, R H.]]
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[[Category: Smith RH]]
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[[Category: Strelow, J M.]]
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[[Category: Strelow JM]]
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[[Category: Walker, A.]]
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[[Category: Walker A]]
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[[Category: Watson, S P.]]
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[[Category: Watson SP]]
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[[Category: Extracellular matrix]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Matrix metalloprotease mmp-12 complex structure]]
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[[Category: Metal-binding]]
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[[Category: Metalloprotease]]
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[[Category: Polymorphism]]
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[[Category: Protease]]
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[[Category: Secreted]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 23 08:21:32 2009''
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Current revision

MMP12 complex with a beta hydroxy carboxylic acid

PDB ID 2wo9

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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