6ald
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 6ALD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]] with 2FP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ | + | 6ALD is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]] with 2FP as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Fructose-bisphosphate_aldolase Fructose-bisphosphate aldolase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.2.13 4.1.2.13]]. Structure known Active Sites: CAT and CTB. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=6ALD OCA]]. |
==Reference== | ==Reference== | ||
Structure of a fructose-1,6-bis(phosphate) aldolase liganded to its natural substrate in a cleavage-defective mutant at 2.3 A(,)., Choi KH, Mazurkie AS, Morris AJ, Utheza D, Tolan DR, Allen KN, Biochemistry. 1999 Sep 28;38(39):12655-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10504235 10504235] | Structure of a fructose-1,6-bis(phosphate) aldolase liganded to its natural substrate in a cleavage-defective mutant at 2.3 A(,)., Choi KH, Mazurkie AS, Morris AJ, Utheza D, Tolan DR, Allen KN, Biochemistry. 1999 Sep 28;38(39):12655-64. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10504235 10504235] | ||
| + | [[Category: Fructose-bisphosphate aldolase]] | ||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: michaelis complex]] | [[Category: michaelis complex]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:37:14 2007'' |
Revision as of 08:32, 30 October 2007
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RABBIT MUSCLE ALDOLASE A/FRUCTOSE-1,6-BISPHOSPHATE COMPLEX
Overview
Class I fructose-1,6-bis(phosphate) aldolase is a glycolytic enzyme that, catalyzes the cleavage of fructose 1,6-bis(phosphate) through a covalent, Schiff base intermediate. Although the atomic structure of this enzyme is, known, assigning catalytic roles to the various enzymic active-site, residues has been hampered by the lack of a structure for the, enzyme-substrate complex. A mutant aldolase, K146A, is unable to cleave, the C3-C4 bond of the hexose while retaining the ability to form the, covalent intermediate, although at a greatly diminished rate. The, structure of rabbit muscle K146A-aldolase A, in complex with its native, substrate, fructose 1,6-bis(phosphate), is determined to 2.3 A resolution, by molecular replacement. The density at the hexose binding site differs, between ... [(full description)]
About this Structure
6ALD is a [Single protein] structure of sequence from [Oryctolagus cuniculus] with 2FP as [ligand]. Active as [Fructose-bisphosphate aldolase], with EC number [4.1.2.13]. Structure known Active Sites: CAT and CTB. Full crystallographic information is available from [OCA].
Reference
Structure of a fructose-1,6-bis(phosphate) aldolase liganded to its natural substrate in a cleavage-defective mutant at 2.3 A(,)., Choi KH, Mazurkie AS, Morris AJ, Utheza D, Tolan DR, Allen KN, Biochemistry. 1999 Sep 28;38(39):12655-64. PMID:10504235
Page seeded by OCA on Tue Oct 30 10:37:14 2007
