1p1y
From Proteopedia
(New page: 200px<br /><applet load="1p1y" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p1y, resolution 2.10Å" /> '''Crystal structure of...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1p1y.gif|left|200px]]<br /><applet load="1p1y" size=" | + | [[Image:1p1y.gif|left|200px]]<br /><applet load="1p1y" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="1p1y, resolution 2.10Å" /> | caption="1p1y, resolution 2.10Å" /> | ||
'''Crystal structure of a continuous three-dimensional DNA lattice from d(GGACAGATGGGAG)'''<br /> | '''Crystal structure of a continuous three-dimensional DNA lattice from d(GGACAGATGGGAG)'''<br /> | ||
==Overview== | ==Overview== | ||
| - | DNA has proved to be a versatile material for the rational design and | + | DNA has proved to be a versatile material for the rational design and assembly of nanometer scale objects. Here we report the crystal structure of a continuous three-dimensional DNA lattice formed by the self-assembly of a DNA 13-mer. The structure consists of stacked layers of parallel helices with adjacent layers linked through parallel-stranded base pairing. The hexagonal lattice geometry contains solvent channels that appear large enough to allow 3'-linked guest molecules into the crystal. We have successfully used these parallel base pairs to design and produce crystals with greatly enlarged solvent channels. This lattice may have applications as a molecular scaffold for structure determination of guest molecules, as a molecular sieve, or in the assembly of molecular electronics. Predictable non-Watson-Crick base pairs, like those described here, may present a new tool in structural DNA nanotechnology. |
==About this Structure== | ==About this Structure== | ||
| - | 1P1Y is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1P1Y is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P1Y OCA]. |
==Reference== | ==Reference== | ||
Crystal structure of a continuous three-dimensional DNA lattice., Paukstelis PJ, Nowakowski J, Birktoft JJ, Seeman NC, Chem Biol. 2004 Aug;11(8):1119-26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15324813 15324813] | Crystal structure of a continuous three-dimensional DNA lattice., Paukstelis PJ, Nowakowski J, Birktoft JJ, Seeman NC, Chem Biol. 2004 Aug;11(8):1119-26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15324813 15324813] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Birktoft, J | + | [[Category: Birktoft, J J.]] |
[[Category: Nowakowski, J.]] | [[Category: Nowakowski, J.]] | ||
| - | [[Category: Paukstelis, P | + | [[Category: Paukstelis, P J.]] |
| - | [[Category: Seeman, N | + | [[Category: Seeman, N C.]] |
[[Category: MG]] | [[Category: MG]] | ||
[[Category: continuous three-dimensional dna lattice]] | [[Category: continuous three-dimensional dna lattice]] | ||
[[Category: parallel-stranded base pairs]] | [[Category: parallel-stranded base pairs]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:24:11 2008'' |
Revision as of 12:24, 21 February 2008
|
Crystal structure of a continuous three-dimensional DNA lattice from d(GGACAGATGGGAG)
Overview
DNA has proved to be a versatile material for the rational design and assembly of nanometer scale objects. Here we report the crystal structure of a continuous three-dimensional DNA lattice formed by the self-assembly of a DNA 13-mer. The structure consists of stacked layers of parallel helices with adjacent layers linked through parallel-stranded base pairing. The hexagonal lattice geometry contains solvent channels that appear large enough to allow 3'-linked guest molecules into the crystal. We have successfully used these parallel base pairs to design and produce crystals with greatly enlarged solvent channels. This lattice may have applications as a molecular scaffold for structure determination of guest molecules, as a molecular sieve, or in the assembly of molecular electronics. Predictable non-Watson-Crick base pairs, like those described here, may present a new tool in structural DNA nanotechnology.
About this Structure
1P1Y is a Protein complex structure of sequences from [1] with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of a continuous three-dimensional DNA lattice., Paukstelis PJ, Nowakowski J, Birktoft JJ, Seeman NC, Chem Biol. 2004 Aug;11(8):1119-26. PMID:15324813
Page seeded by OCA on Thu Feb 21 14:24:11 2008
