3hhm

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===Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin===
===Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin===
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{{ABSTRACT_PUBMED_19805105}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
3HHM is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHM OCA].
3HHM is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HHM OCA].
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==Reference==
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<ref group="xtra">PMID:19805105</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]]
[[Category: Phosphatidylinositol-4,5-bisphosphate 3-kinase]]
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[[Category: Wortmannin]]
[[Category: Wortmannin]]
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Revision as of 07:50, 21 October 2009

Image:3hhm.png

Template:STRUCTURE 3hhm

Contents

Crystal structure of p110alpha H1047R mutant in complex with niSH2 of p85alpha and the drug wortmannin

Template:ABSTRACT PUBMED 19805105

Disease

Known disease associated with this structure: Breast cancer, somatic OMIM:[171834], Colorectal cancer, somatic OMIM:[171834], Gastric cancer, somatic OMIM:[171834], Hepatocellular carcinoma, somatic OMIM:[171834], Keratosis, seborrheic, somatic OMIM:[171834], Nevus, epidermal OMIM:[171834], Nonsmall cell lung cancer, somatic OMIM:[171834], Ovarian cancer, somatic OMIM:[171834]

About this Structure

3HHM is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Mandelker D, Gabelli SB, Schmidt-Kittler O, Zhu J, Cheong I, Huang CH, Kinzler KW, Vogelstein B, Amzel LM. A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc Natl Acad Sci U S A. 2009 Oct 6;106(40):16996-7001. Epub 2009 Sep 23. PMID:19805105

Page seeded by OCA on Wed Oct 21 09:50:12 2009

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